GATA1 (Ab-142) Antibody (PACO23542)
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주문- SKU:
- PACO23542
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | GATA1 (Ab-142) Antibody (PACO23542) |
Antibody SKU: | PACO23542 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Peptide sequence around aa.140~144 (R-L-S-P-D) derived from Human GATA1. |
Form: | Liquid |
Storage Buffer: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from 3T3 cells using GATA1(Ab-142) Antibody. | |
Immunofluorescence staining of methanol-fixed Hela cells using GATA1(Ab-142) Antibody. | |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using GATA1(Ab-142) Antibody(left) or the same antibody preincubated with blocking peptide(right). |
Background: | GATA1 encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. |
Synonyms: | GAT1; GATA1; GF-1; NF-E1; |
UniProt Protein Function: | Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). |
NCBI Summary: | This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008] |
UniProt Code: | P15976 |
NCBI GenInfo Identifier: | 120956 |
NCBI Gene ID: | 2623 |
NCBI Accession: | P15976.1 |
UniProt Secondary Accession: | P15976,Q96GB8, |
UniProt Related Accession: | P15976 |
Molecular Weight: | 34,232 Da |
NCBI Full Name: | Erythroid transcription factor |
NCBI Synonym Full Names: | GATA binding protein 1 |
NCBI Official Symbol: | GATA1 |
NCBI Official Synonym Symbols: | GF1; GF-1; NFE1; XLTT; ERYF1; NF-E1; XLANP; XLTDA; GATA-1 |
NCBI Protein Information: | erythroid transcription factor |
UniProt Protein Name: | Erythroid transcription factor |
UniProt Synonym Protein Names: | Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein |
Protein Family: | GATA transcription factor |
UniProt Gene Name: | GATA1 |
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