EPHA7 (Ab-791) Antibody (PACO21644)
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주문- SKU:
- PACO21644
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | EPHA7 (Ab-791) Antibody (PACO21644) |
Antibody SKU: | PACO21644 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from Internal of human EPHA7. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from JK cells (Lane 2) and K562 cells (Lane 3), using EPHA7 (Ab-791) antiobdy. The lane on the left is treated with synthesized peptide. |
Background: | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. |
Synonyms: | EHK-3; EHK3; EK11; EPH homology kinase 3; Eph homology kinase-3 |
UniProt Protein Function: | EphA7: a widely-expressed receptor tyrosine kinase of the Eph family. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A2, -A3, -A4 and -A5. Contains 1 sterile alpha motif (SAM) and two fibronectin type III domains. |
UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Eph family Chromosomal Location of Human Ortholog: 6q16.1 Cellular Component: plasma membrane Molecular Function:axon guidance receptor activity; chemorepellent activity; GPI-linked ephrin receptor activity; protein binding; protein-tyrosine kinase activity Biological Process: brain development; branching morphogenesis of a nerve; ephrin receptor signaling pathway; negative chemotaxis; phosphorylation; positive regulation of neuron apoptosis; regulation of caspase activity; regulation of cell-cell adhesion; regulation of peptidyl-tyrosine phosphorylation; regulation of protein amino acid autophosphorylation |
NCBI Summary: | This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] |
UniProt Code: | Q15375 |
NCBI GenInfo Identifier: | 146345416 |
NCBI Gene ID: | 2045 |
NCBI Accession: | Q15375.3 |
UniProt Secondary Accession: | Q15375,Q59G40, Q5VTU0, Q8N368, Q9H124, A0AUX7, B2R8W1 B7ZLJ9, B7ZLK0, |
UniProt Related Accession: | Q15375 |
Molecular Weight: | 50,521 Da |
NCBI Full Name: | Ephrin type-A receptor 7 |
NCBI Synonym Full Names: | EPH receptor A7 |
NCBI Official Symbol: | EPHA7 |
NCBI Official Synonym Symbols: | EHK3; EK11; EHK-3; HEK11 |
NCBI Protein Information: | ephrin type-A receptor 7 |
UniProt Protein Name: | Ephrin type-A receptor 7 |
UniProt Synonym Protein Names: | EPH homology kinase 3; EHK-3; EPH-like kinase 11; EK11; hEK11 |
Protein Family: | Ephrin type-A receptor |
UniProt Gene Name: | EPHA7 |
UniProt Entry Name: | EPHA7_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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