DEDD Antibody (PACO08800)
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주문- SKU:
- PACO08800
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DEDD Antibody (PACO08800) |
Antibody SKU: | PACO08800 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human DEDD |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | death effector domain containing;DEDD;CASP8IP1;DEDD1;DEFT;FLDED1;KE05 ; |
UniProt Protein Function: | DEDD: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nucleolus Chromosomal Location of Human Ortholog: 1q23.3 Cellular Component: cytoplasm; nucleolus Molecular Function:DNA binding; protein binding |
NCBI Summary: | This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O75618 |
NCBI GenInfo Identifier: | 21759089 |
NCBI Gene ID: | 9191 |
NCBI Accession: | O75618.1 |
UniProt Secondary Accession: | O75618,O60737, D3DVF5, |
UniProt Related Accession: | O75618 |
Molecular Weight: | 40,418 Da |
NCBI Full Name: | Death effector domain-containing protein |
NCBI Synonym Full Names: | death effector domain containing |
NCBI Official Symbol: | DEDD |
NCBI Official Synonym Symbols: | DEFT; KE05; DEDD1; FLDED1; CASP8IP1 |
NCBI Protein Information: | death effector domain-containing protein |
UniProt Protein Name: | Death effector domain-containing protein |
UniProt Synonym Protein Names: | DEDPro1; Death effector domain-containing testicular molecule; FLDED-1 |
Protein Family: | Death effector domain-containing protein |
UniProt Gene Name: | DEDD |
UniProt Entry Name: | DEDD_HUMAN |