DEDD2 Antibody (PACO43845)
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주문- SKU:
- PACO43845
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | DEDD2 Antibody (PACO43845) |
Antibody SKU: | PACO43845 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human DNA-binding death effector domain-containing protein 2 protein (1-240AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43845 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO43845 at dilution of 1:100. |
Background: | May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. |
Synonyms: | DNA-binding death effector domain-containing protein 2 (DED-containing protein FLAME-3) (FADD-like anti-apoptotic molecule 3), DEDD2, FLAME3 |
UniProt Protein Function: | DEDD2: May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nucleolus Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: nucleolus; nucleoplasm Molecular Function:DNA binding; protein binding Biological Process: apoptotic nuclear changes; induction of apoptosis via death domain receptors |
NCBI Summary: | This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] |
UniProt Code: | Q8WXF8 |
NCBI GenInfo Identifier: | 47116024 |
NCBI Gene ID: | 162989 |
NCBI Accession: | Q8WXF8.1 |
UniProt Secondary Accession: | Q8WXF8,Q8NBR2, Q8NES1, Q8TAA8, Q96D35, |
UniProt Related Accession: | Q8WXF8 |
Molecular Weight: | 35,577 Da |
NCBI Full Name: | DNA-binding death effector domain-containing protein 2 |
NCBI Synonym Full Names: | death effector domain containing 2 |
NCBI Official Symbol: | DEDD2 |
NCBI Official Synonym Symbols: | FLAME-3 |
NCBI Protein Information: | DNA-binding death effector domain-containing protein 2 |
UniProt Protein Name: | DNA-binding death effector domain-containing protein 2 |
UniProt Synonym Protein Names: | DED-containing protein FLAME-3; FADD-like anti-apoptotic molecule 3 |
Protein Family: | DNA-binding death effector domain-containing protein |
UniProt Gene Name: | DEDD2 |
UniProt Entry Name: | DEDD2_HUMAN |