CPT1A Antibody (PACO45754)
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주문- SKU:
- PACO45754
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | CPT1A Antibody (PACO45754) |
Antibody SKU: | PACO45754 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:2000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Carnitine O-palmitoyltransferase 1, liver isoform protein (301-600AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: HepG2 whole cell lysate, Mouse kidney tissue. All lanes: CPT1A antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 89, 87 kDa. Observed band size: 89 kDa.. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO45754 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human heart tissue using PACO45754 at dilution of 1:100. |
Background: | Catalyzes the transfer of the acyl group of long-chain fatty acid, CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acid, and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism. |
Synonyms: | Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A), CPT1A, CPT1 |
UniProt Protein Function: | CPT1A: Belongs to the carnitine/choline acetyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Lipid Metabolism - fatty acid; Membrane protein, integral; EC 2.3.1.21; Mitochondrial; Membrane protein, multi-pass; Transferase Chromosomal Location of Human Ortholog: 11q13.2 Cellular Component: mitochondrial outer membrane; membrane; mitochondrion; mitochondrial inner membrane; integral to mitochondrial outer membrane Molecular Function:identical protein binding; carnitine O-palmitoyltransferase activity Biological Process: circadian rhythm; response to drug; eating behavior; glucose metabolic process; long-chain fatty acid metabolic process; carnitine shuttle; cellular lipid metabolic process; response to organic cyclic substance; positive regulation of fatty acid beta-oxidation; fatty acid beta-oxidation; triacylglycerol metabolic process; epithelial cell differentiation; carnitine metabolic process; regulation of insulin secretion; protein homooligomerization Disease: Carnitine Palmitoyltransferase I Deficiency |
NCBI Summary: | The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P50416 |
NCBI GenInfo Identifier: | 56405343 |
NCBI Gene ID: | 1374 |
NCBI Accession: | P50416.2 |
UniProt Secondary Accession: | P50416,Q8TCU0, Q9BWK0, |
UniProt Related Accession: | P50416 |
Molecular Weight: | 773 |
NCBI Full Name: | Carnitine O-palmitoyltransferase 1, liver isoform |
NCBI Synonym Full Names: | carnitine palmitoyltransferase 1A (liver) |
NCBI Official Symbol: | CPT1A |
NCBI Official Synonym Symbols: | CPT1; CPT1-L; L-CPT1 |
NCBI Protein Information: | carnitine O-palmitoyltransferase 1, liver isoform; CPT I; CPTI-L; carnitine palmitoyltransferase I, liver; carnitine O-palmitoyltransferase I, liver isoform |
UniProt Protein Name: | Carnitine O-palmitoyltransferase 1, liver isoform |
UniProt Synonym Protein Names: | Carnitine O-palmitoyltransferase I, liver isoform; CPT I; CPTI-L; Carnitine palmitoyltransferase 1A |
Protein Family: | Carnitine O-palmitoyltransferase |
UniProt Gene Name: | CPT1A |
UniProt Entry Name: | CPT1A_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |