CPT1A Antibody (PACO14285)
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주문- SKU:
- PACO14285
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | CPT1A Antibody (PACO14285) |
Antibody SKU: | PACO14285 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human CPT1A |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO14285(CPT1A Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14285(CPT1A Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The mitochondrial oxidation of long-chain fatty acid, is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid, beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | carnitine palmitoyltransferase 1A (liver) |
UniProt Protein Function: | CPT1A: Belongs to the carnitine/choline acetyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Lipid Metabolism - fatty acid; Membrane protein, integral; EC 2.3.1.21; Mitochondrial; Membrane protein, multi-pass; Transferase Chromosomal Location of Human Ortholog: 11q13.2 Cellular Component: mitochondrial outer membrane; membrane; mitochondrion; mitochondrial inner membrane; integral to mitochondrial outer membrane Molecular Function:identical protein binding; carnitine O-palmitoyltransferase activity Biological Process: circadian rhythm; response to drug; eating behavior; glucose metabolic process; long-chain fatty acid metabolic process; carnitine shuttle; cellular lipid metabolic process; response to organic cyclic substance; positive regulation of fatty acid beta-oxidation; fatty acid beta-oxidation; triacylglycerol metabolic process; epithelial cell differentiation; carnitine metabolic process; regulation of insulin secretion; protein homooligomerization Disease: Carnitine Palmitoyltransferase I Deficiency |
NCBI Summary: | The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P50416 |
NCBI GenInfo Identifier: | 56405343 |
NCBI Gene ID: | 1374 |
NCBI Accession: | P50416.2 |
UniProt Secondary Accession: | P50416,Q8TCU0, Q9BWK0, |
UniProt Related Accession: | P50416 |
Molecular Weight: | 773 |
NCBI Full Name: | Carnitine O-palmitoyltransferase 1, liver isoform |
NCBI Synonym Full Names: | carnitine palmitoyltransferase 1A (liver) |
NCBI Official Symbol: | CPT1A |
NCBI Official Synonym Symbols: | CPT1; CPT1-L; L-CPT1 |
NCBI Protein Information: | carnitine O-palmitoyltransferase 1, liver isoform; CPT I; CPTI-L; carnitine palmitoyltransferase I, liver; carnitine O-palmitoyltransferase I, liver isoform |
UniProt Protein Name: | Carnitine O-palmitoyltransferase 1, liver isoform |
UniProt Synonym Protein Names: | Carnitine O-palmitoyltransferase I, liver isoform; CPT I; CPTI-L; Carnitine palmitoyltransferase 1A |
Protein Family: | Carnitine O-palmitoyltransferase |
UniProt Gene Name: | CPT1A |
UniProt Entry Name: | CPT1A_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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