CFL1 Antibody (PACO46354)
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주문- SKU:
- PACO46354
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | CFL1 Antibody (PACO46354) |
Antibody SKU: | PACO46354 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Cofilin-1 protein (4-144AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human appendix tissue using PACO46354 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO46354 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO46354 at dilution of 1:100. |
Background: | Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity). |
Synonyms: | Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform), CFL1, CFL |
UniProt Protein Function: | Cofilin-1: a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Cytoskeletal Chromosomal Location of Human Ortholog: 11q13 Cellular Component: cortical actin cytoskeleton; cytoplasm; extracellular space; focal adhesion; intercellular junction; membrane; nuclear matrix; nucleus; vesicle Molecular Function:actin binding; protein binding Biological Process: actin cytoskeleton organization and biogenesis; actin filament depolymerization; axon guidance; blood coagulation; cytokinesis after mitosis; cytoskeleton organization and biogenesis; ephrin receptor signaling pathway; establishment of cell polarity; innate immune response; negative regulation of apoptosis; neural crest cell migration; neural fold formation; platelet activation; platelet degranulation; positive regulation of actin filament depolymerization; protein amino acid phosphorylation; regulation of cell morphogenesis; response to amino acid stimulus; response to virus; Rho protein signal transduction |
NCBI Summary: | The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004] |
UniProt Code: | P23528 |
NCBI GenInfo Identifier: | 116848 |
NCBI Gene ID: | 1072 |
NCBI Accession: | P23528.3 |
UniProt Secondary Accession: | P23528,Q53Y87, Q9UCA2, B3KUQ1, |
UniProt Related Accession: | P23528 |
Molecular Weight: | 18,502 Da |
NCBI Full Name: | Cofilin-1 |
NCBI Synonym Full Names: | cofilin 1 |
NCBI Official Symbol: | CFL1 |
NCBI Official Synonym Symbols: | CFL; cofilin; HEL-S-15 |
NCBI Protein Information: | cofilin-1 |
UniProt Protein Name: | Cofilin-1 |
UniProt Synonym Protein Names: | 18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform |
Protein Family: | Cofilin |
UniProt Gene Name: | CFL1 |
UniProt Entry Name: | COF1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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