APRT Antibody (PACO43184)
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주문- SKU:
- PACO43184
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | APRT Antibody (PACO43184) |
Antibody SKU: | PACO43184 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Adenine phosphoribosyltransferase protein (1-180AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO43184 at dilution of 1:100. |
Background: | Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. |
Synonyms: | Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7), APRT |
UniProt Protein Function: | APRT: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Defects in APRT are the cause of adenine phosphoribosyltransferase deficiency (APRTD); also known as 2,8-dihydroxyadenine urolithiasis. An enzymatic deficiency that can lead to urolithiasis and renal failure. Patients have 2,8-dihydroxyadenine (DHA) urinary stones. Belongs to the purine/pyrimidine phosphoribosyltransferase family. |
UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; Transferase; EC 2.4.2.7 Chromosomal Location of Human Ortholog: 16q24 Cellular Component: nucleoplasm; cytoplasm; cytosol Molecular Function:adenine binding; adenine phosphoribosyltransferase activity; AMP binding Biological Process: grooming behavior; lactation; cellular response to insulin stimulus; nucleobase, nucleoside and nucleotide metabolic process; adenine salvage; purine salvage; purine base metabolic process Disease: Adenine Phosphoribosyltransferase Deficiency |
NCBI Summary: | Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P07741 |
NCBI GenInfo Identifier: | 114074 |
NCBI Gene ID: | 353 |
NCBI Accession: | P07741.2 |
UniProt Secondary Accession: | P07741,Q3KP55, Q68DF9, G5E9J2, |
UniProt Related Accession: | P07741 |
Molecular Weight: | 14,557 Da |
NCBI Full Name: | Adenine phosphoribosyltransferase |
NCBI Synonym Full Names: | adenine phosphoribosyltransferase |
NCBI Official Symbol: | APRT |
NCBI Official Synonym Symbols: | AMP; APRTD |
NCBI Protein Information: | adenine phosphoribosyltransferase; AMP diphosphorylase; AMP pyrophosphorylase; transphosphoribosidase |
UniProt Protein Name: | Adenine phosphoribosyltransferase |
Protein Family: | Probable adenine phosphoribosyltransferase |
UniProt Gene Name: | APRT |
UniProt Entry Name: | APT_HUMAN |