NAPRT Antibody (PACO28494)
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주문- SKU:
- PACO28494
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NAPRT Antibody (PACO28494) |
Antibody SKU: | PACO28494 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Nicotinate phosphoribosyltransferase protein (1-310AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.1mol/L NaCl, 15mmol/L NaN3, PH7.2 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot Positive WB detected in: HepG2 whole cell lysate, Mouse liver tissue, Mouse kidney tissue All lanes: NAPRT antibody at 4µg/ml Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 58, 61, 57 kDa Observed band size: 58 kDa . |
Background: | Catalyzes the conversion of nicotinic acid, (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells. |
Synonyms: | Nicotinate phosphoribosyltransferase (NAPRTase) (EC 6.3.4.21) (FHA-HIT-interacting protein) (Nicotinate phosphoribosyltransferase domain-containing protein 1), NAPRT, FHIP NAPRT1 |
UniProt Protein Function: | NAPRT1: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells. Belongs to the NAPRTase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 6.3.4.21; Transferase Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: cytosol; extracellular region Molecular Function:nicotinate phosphoribosyltransferase activity; protein binding Biological Process: neutrophil degranulation; response to oxidative stress |
NCBI Summary: | Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q6XQN6 |
NCBI GenInfo Identifier: | 166221824 |
NCBI Gene ID: | 93100 |
NCBI Accession: | Q6XQN6.2 |
UniProt Secondary Accession: | Q6XQN6,Q6PJL1, Q6XQN4, Q6XQN5, Q8N5E8, Q9BRG0, A7BFI3 |
UniProt Related Accession: | Q6XQN6 |
Molecular Weight: | 58kDa |
NCBI Full Name: | Nicotinate phosphoribosyltransferase |
NCBI Synonym Full Names: | nicotinate phosphoribosyltransferase |
NCBI Official Symbol: | NAPRT |
NCBI Official Synonym Symbols: | NAPRT1; PP3856 |
NCBI Protein Information: | nicotinate phosphoribosyltransferase |
UniProt Protein Name: | Nicotinate phosphoribosyltransferase |
UniProt Synonym Protein Names: | FHA-HIT-interacting protein; Nicotinate phosphoribosyltransferase domain-containing protein 1 |
UniProt Gene Name: | NAPRT |