Anti-MICU1 Antibody (MACO0140)
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주문- SKU:
- MACO0140
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Mouse
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Monoclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Product Name: | Anti-MICU1 Antibody |
Product Sku: | MACO0140 |
Size: | 50ug |
Host Species: | Mouse |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:5000, IHC:1:50-1:500 |
Species Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant Protein |
Form: | Liquid |
Storage Buffer: | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
Purification Method: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Clonality: | Monoclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Background: | |
Synonyms: | Calcium uptake protein 1, mitochondrial |
Western blot analysis of 1) MCF7, 2) Mouse Brain Tissue, 3) Rat Brain Tissue using MICU1 Monoclonal Antibody. | |
Immunohistochemical analysis of paraffin-embedded Human Lung Carcinoma using MICU1 Monoclonal Antibody. |
UniProt Protein Function: | MICU1: Key regulator of mitochondrial calcium uptake required for calcium entry into mitochondrion. May act as a calcium sensor via its EF-hand domains, gating the activity of a calcium channel partner. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. Belongs to the MICU1 family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Mitochondrial; Calcium-binding Chromosomal Location of Human Ortholog: 10q22.1 Cellular Component: intracellular; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion Molecular Function:calcium ion binding; identical protein binding; protein binding; protein heterodimerization activity Biological Process: defense response; elevation of mitochondrial calcium ion concentration; mitochondrial calcium ion homeostasis; mitochondrial calcium ion transport; protein homooligomerization Disease: Myopathy With Extrapyramidal Signs |
NCBI Summary: | This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013] |
UniProt Code: | Q9BPX6 |
NCBI GenInfo Identifier: | 74761192 |
NCBI Gene ID: | 10367 |
NCBI Accession: | Q9BPX6.1 |
UniProt Secondary Accession: | Q9BPX6,O75785, Q9H9N6, Q9UFX0, A8MV96, B3KN20, B4DJH9 B4DPI1, B5MBY3, D3YTJ3, |
UniProt Related Accession: | Q9BPX6 |
Molecular Weight: | 31,931 Da |
NCBI Full Name: | Calcium uptake protein 1, mitochondrial |
NCBI Synonym Full Names: | mitochondrial calcium uptake 1 |
NCBI Official Symbol: | MICU1Â Â |
NCBI Official Synonym Symbols: | CALC; EFHA3; MPXPS; CBARA1Â Â |
NCBI Protein Information: | calcium uptake protein 1, mitochondrial |
UniProt Protein Name: | Calcium uptake protein 1, mitochondrial |
UniProt Synonym Protein Names: | Atopy-related autoantigen CALC; ara CALC; Calcium-binding atopy-related autoantigen 1; Allergen: Hom s 4 |
Protein Family: | Calcium uptake protein |
UniProt Gene Name: | MICU1Â Â |
UniProt Entry Name: | MICU1_HUMAN |