Anti-LALBA Antibody (MACO0163)
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주문- SKU:
- MACO0163
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Bovine
- Host Species:
- Mouse
- Isotype:
- IgG1
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Monoclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Product Name: | Anti-LALBA Antibody |
Product Sku: | MACO0163 |
Size: | 100ul |
Host Species: | Mouse |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:5000 |
Species Reactivity: | Human, Bovine |
Immunogen: | Recombinant Protein |
Form: | Liquid |
Storage Buffer: | Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Monoclonal |
Isotype: | IgG1 |
Conjugate: | Non-conjugated |
Background: | In primates, alpha-lactalbumin expression is upregulated in response to the hormone prolactin and increases the production of lactose.α-Lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and Beta-1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. |
Synonyms: | Lysozyme-like protein 5; LYZL5; SLLP-X; SPACA5; SPACA5A; SPACA5B; sperm acrosome associated 5B |
UniProt Protein Function: | LALBA: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. Belongs to the glycosyl hydrolase 22 family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Transferase; Apoptosis Chromosomal Location of Human Ortholog: 12q13 Cellular Component: extracellular space; Golgi lumen; Golgi membrane Biological Process: apoptosis; cell-cell signaling; defense response to bacterium; lactose biosynthetic process; signal transduction |
NCBI Summary: | This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008] |
UniProt Code: | P00709 |
NCBI GenInfo Identifier: | 126001 |
NCBI Gene ID: | 3906 |
NCBI Accession: | P00709.1 |
UniProt Secondary Accession: | P00709,Q6FGX0, Q9UDK4, |
UniProt Related Accession: | P00709 |
Molecular Weight: | 16,225 Da |
NCBI Full Name: | Alpha-lactalbumin |
NCBI Synonym Full Names: | lactalbumin alpha |
NCBI Official Symbol: | LALBA |
NCBI Official Synonym Symbols: | LYZG |
NCBI Protein Information: | alpha-lactalbumin |
UniProt Protein Name: | Alpha-lactalbumin |
UniProt Synonym Protein Names: | Lactose synthase B protein; Lysozyme-like protein 7 |
Protein Family: | Alpha-lactalbumin |
UniProt Gene Name: | LALBA |
UniProt Entry Name: | LALBA_HUMAN |