Anti-FAAH Antibody (RACO0513)
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주문- SKU:
- RACO0513
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Application:
- IHC
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Product Name: | FAAH Antibody |
Product SKU: | RACO0513 |
Size: | 50ul |
Host Species: | Homo sapiens (Human) |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | A synthesized peptide derived from human FAAH1 |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Affinity-chromatography |
Clonality: | Monoclonal |
Isotype: | Rabbit IgG |
Conjugate: | Non-conjugated |
Background: | Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. |
Synonyms: | Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidohydrolase 1) (Oleamide hydrolase 1), FAAH, FAAH1 |
IHC image of RACO0513 diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. | |
Western Blot. Positive WB detected in MCF-7 whole cell lysate THP-1 whole cell lysate 293 whole cell lysate HepG2 whole cell lysate Mouse Liver whole cell lysate All lanes FAAH1 Antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 64 kDa. Observed band size: 64 kDa. |
UniProt Protein Function: | FAAH: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. Homodimer. Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate. Inhibited by O-aryl carbamates and alpha-keto heterocytes. Belongs to the amidase family. |
UniProt Protein Details: | Protein type:EC 3.5.1.99; Membrane protein, integral; Hydrolase Chromosomal Location of Human Ortholog: 1p35-p34 Cellular Component: cytoskeleton; cytoplasm; integral to membrane; endomembrane system Molecular Function:fatty acid amide hydrolase activity; carbon-nitrogen ligase activity, with glutamine as amido-N-donor; acylglycerol lipase activity Biological Process: fatty acid catabolic process Disease: Polysubstance Abuse, Susceptibility To |
NCBI Summary: | This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008] |
UniProt Code: | O00519 |
NCBI GenInfo Identifier: | 60416391 |
NCBI Gene ID: | 2166 |
NCBI Accession: | O00519.2 |
UniProt Related Accession: | O00519 |
Molecular Weight: | ~ 63kDa |
NCBI Full Name: | Fatty-acid amide hydrolase 1 |
NCBI Synonym Full Names: | fatty acid amide hydrolase |
NCBI Official Symbol: | FAAHÂ Â |
NCBI Official Synonym Symbols: | PSAB; FAAH-1Â Â |
NCBI Protein Information: | fatty-acid amide hydrolase 1 |
UniProt Protein Name: | Fatty-acid amide hydrolase 1 |
UniProt Synonym Protein Names: | Anandamide amidohydrolase 1; Oleamide hydrolase 1 |
Protein Family: | Fatty-acid amide hydrolase |
UniProt Gene Name: | FAAHÂ Â |
UniProt Entry Name: | FAAH1_HUMAN |