FAAH Antibody (PACO49582)
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주문- SKU:
- PACO49582
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | FAAH Antibody (PACO49582) |
Antibody SKU: | PACO49582 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Fatty-acid, amide hydrolase 1 protein (205-342AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO49582 at dilution of 1:100. | |
Immunofluorescent analysis of MCF-7 cells using PACO49582 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO49582 at dilution of 1:100. |
Background: | Degrades bioactive fatty acid, amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acid, , thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. |
Synonyms: | Fatty-acid, amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidohydrolase 1) (Oleamide hydrolase 1), FAAH, FAAH1 |
UniProt Protein Function: | FAAH: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. Homodimer. Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate. Inhibited by O-aryl carbamates and alpha-keto heterocytes. Belongs to the amidase family. |
UniProt Protein Details: | Protein type:EC 3.5.1.99; Membrane protein, integral; Hydrolase Chromosomal Location of Human Ortholog: 1p35-p34 Cellular Component: cytoskeleton; cytoplasm; integral to membrane; endomembrane system Molecular Function:fatty acid amide hydrolase activity; carbon-nitrogen ligase activity, with glutamine as amido-N-donor; acylglycerol lipase activity Biological Process: fatty acid catabolic process Disease: Polysubstance Abuse, Susceptibility To |
NCBI Summary: | This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008] |
UniProt Code: | O00519 |
NCBI GenInfo Identifier: | 60416391 |
NCBI Gene ID: | 2166 |
NCBI Accession: | O00519.2 |
UniProt Related Accession: | O00519 |
Molecular Weight: | ~ 63kDa |
NCBI Full Name: | Fatty-acid amide hydrolase 1 |
NCBI Synonym Full Names: | fatty acid amide hydrolase |
NCBI Official Symbol: | FAAH |
NCBI Official Synonym Symbols: | PSAB; FAAH-1 |
NCBI Protein Information: | fatty-acid amide hydrolase 1 |
UniProt Protein Name: | Fatty-acid amide hydrolase 1 |
UniProt Synonym Protein Names: | Anandamide amidohydrolase 1; Oleamide hydrolase 1 |
Protein Family: | Fatty-acid amide hydrolase |
UniProt Gene Name: | FAAH |
UniProt Entry Name: | FAAH1_HUMAN |