Anti-EPCAM Antibody (RACO0234)
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주문- SKU:
- RACO0234
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Product Name: | EPCAM Antibody |
Product SKU: | RACO0234 |
Size: | 50ul |
Host Species: | Homo sapiens (Human) |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:5000 |
Species Reactivity: | Human |
Immunogen: | A synthesized peptide derived from human EpCAM |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Affinity-chromatography |
Clonality: | Monoclonal |
Isotype: | Rabbit IgG |
Conjugate: | Non-conjugated |
Background: | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. |
Synonyms: | Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326), EPCAM, GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1 |
Western Blot. Positive WB detected in HT-29 whole cell lysate All lanes EPCAM antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 35 kDa. Observed band size: 35 kDa. |
UniProt Protein Function: | EPCAM: a single-pass type I membrane protein of the EPCAM family. May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas including pancreatic carcinoma. May be a marker of cancer stem cells. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis Cellular Component: tight junction; cell surface; membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane; integral to membrane; cell junction; lateral plasma membrane Molecular Function:protein complex binding Biological Process: positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; stem cell differentiation; negative regulation of apoptosis |
UniProt Code: | P16422 |
NCBI GenInfo Identifier: | 112293275 |
NCBI Gene ID: | 17075 |
NCBI Accession: | NP_032558.2 |
UniProt Secondary Accession: | P16422,Q61512, |
UniProt Related Accession: | Q99JW5 |
Molecular Weight: | |
NCBI Full Name: | epithelial cell adhesion molecule |
NCBI Synonym Full Names: | epithelial cell adhesion molecule |
NCBI Official Symbol: | Epcam  |
NCBI Official Synonym Symbols: | EGP; Ly74; gp40; CD326; EGP-2; TROP1; Egp314; Ep-CAM; EpCAM1; Tacsd1; GA733-2; Tacstd1Â Â |
NCBI Protein Information: | epithelial cell adhesion molecule |
UniProt Protein Name: | Epithelial cell adhesion molecule |
UniProt Synonym Protein Names: | Epithelial glycoprotein 314; EGP314; mEGP314; Protein 289A; Tumor-associated calcium signal transducer 1; CD_antigen: CD326 |
Protein Family: | Epithelial cell adhesion molecule |
UniProt Gene Name: | Epcam  |
UniProt Entry Name: | EPCAM_MOUSE |