Anti-ADRA1A Antibody (CAB7873)
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주문- SKU:
- CAB7873
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Antibody Name: | Anti-ADRA1A Antibody |
Antibody SKU: | CAB7873 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC IF |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthetic peptide of human ADRA1A |
Application: | WB IHC IF |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | BT-474, HL-60, 22Rv1, Raji, Mouse kidney, Mouse heart, Mouse lung |
Immunogen: | A synthetic peptide of human ADRA1A |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 148 |
Uniprot: | P35348 |
Cellular Location: | Cell membrane, Multi-pass membrane protein, Nucleus membrane |
Calculated MW: | 32-52kDa |
Observed MW: | 60kDa |
Synonyms: | ADRA1A, ADRA1C, ADRA1L1, ALPHA1AAR |
Background: | Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. |
UniProt Protein Function: | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. |
NCBI Summary: | Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008] |
UniProt Code: | P35348 |
NCBI GenInfo Identifier: | 1168246 |
NCBI Gene ID: | 148 |
NCBI Accession: | P35348.2 |
UniProt Secondary Accession: | P35348,O60451, Q13675, Q13729, A8K0I3, B0ZBD1, B0ZBD2 B0ZBD4, B0ZBD5, B0ZBD6, B0ZBD8, B0ZBD9, |
UniProt Related Accession: | P35348 |
Molecular Weight: | 40,638 Da |
NCBI Full Name: | Alpha-1A adrenergic receptor |
NCBI Synonym Full Names: | adrenoceptor alpha 1A |
NCBI Official Symbol: | ADRA1A |
NCBI Official Synonym Symbols: | ADRA1C; ADRA1L1; ALPHA1AAR |
NCBI Protein Information: | alpha-1A adrenergic receptor |
UniProt Protein Name: | Alpha-1A adrenergic receptor |
UniProt Synonym Protein Names: | Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c |
Protein Family: | Alpha-1A adrenergic receptor |
UniProt Gene Name: | ADRA1A |
UniProt Entry Name: | ADA1A_HUMAN |
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