Anti-ACTR3 Antibody (RACO0503)
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주문- SKU:
- RACO0503
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Conjugation:
- Unconjugated
Description
Product Name: | ACTR3 Antibody |
Product SKU: | RACO0503 |
Size: | 50ul |
Host Species: | Homo sapiens (Human) |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:5000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | A synthesized peptide derived from human Arp3 |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Affinity-chromatography |
Clonality: | Monoclonal |
Isotype: | Rabbit IgG |
Conjugate: | Non-conjugated |
Background: | Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis. |
Synonyms: | Actin-related protein 3 (Actin-like protein 3), ACTR3, ARP3 |
Western Blot. Positive WB detected in PC-3 whole cell lysate K562 whole cell lysate HL-60 whole cell lysate A549 whole cell lysate Mouse Spleen whole cell lysate Rat Spleen whole cell lysate All lanes Arp3 Antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 48 kDa. Observed band size: 48 kDa. |
UniProt Protein Function: | Arp3: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis. Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1. Belongs to the actin family. ARP3 subfamily. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 2q14.1 Cellular Component: Golgi membrane; Arp2/3 protein complex; focal adhesion; hemidesmosome; membrane; lamellipodium; excitatory synapse; podosome; actin filament; intercellular junction; cytosol; actin cytoskeleton Molecular Function:actin filament binding; protein binding; structural constituent of cytoskeleton; ATP binding Biological Process: response to antibiotic; positive regulation of filopodium formation; axon guidance; meiotic chromosome movement towards spindle pole; asymmetric cell division; regulation of myosin II filament assembly or disassembly; establishment and/or maintenance of cell polarity; ephrin receptor signaling pathway; innate immune response; cytokinesis after meiosis; positive regulation of dendrite morphogenesis; cell motility; response to carbohydrate stimulus; spindle localization |
NCBI Summary: | The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013] |
UniProt Code: | P61158 |
NCBI GenInfo Identifier: | 47117647 |
NCBI Gene ID: | 10096 |
NCBI Accession: | P61158.3 |
UniProt Secondary Accession: | P61158,P32391, Q53QM2, |
UniProt Related Accession: | P61158 |
Molecular Weight: | 47,371 Da |
NCBI Full Name: | Actin-related protein 3 |
NCBI Synonym Full Names: | ARP3 actin-related protein 3 homolog (yeast) |
NCBI Official Symbol: | ACTR3Â Â |
NCBI Official Synonym Symbols: | ARP3Â Â |
NCBI Protein Information: | actin-related protein 3; actin-like protein 3 |
UniProt Protein Name: | Actin-related protein 3 |
UniProt Synonym Protein Names: | Actin-like protein 3 |
UniProt Gene Name: | ACTR3Â Â |
UniProt Entry Name: | ARP3_HUMAN |