ABCC4 Antibody (PACO21292)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO21292
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ABCC4 Antibody (PACO21292) |
Antibody SKU: | PACO21292 |
Size: | 100ul(100ug) |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Recombinant protein of human ABCC4 |
Form: | Liquid |
Storage Buffer: | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Background: | ABCC4 is a member of the ATP-binding Cassette (ABC) transporter family. ABC proteins transport various molecules across cellular membranes by utilizing the energy generated from ATP hydrolysis. There are seven subfamilies of ABC proteins: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. ABCC4 belongs to the MRP subfamily, which is involved in multi-drug resistance, hence it is also named MRP4. ABCC4 is widely expressed in cells and tissues including prostate, kidney proximal tubules, astrocytes and capillary endothelial cells of the brain, platelets, and many cancer cell lines. ABCC4 mediates efflux transport of a wide variety of endogenous and xenobiotic organic anionic compounds. The diversity of substrates determines the biological functions of ABCC4. It regulates cAMP levels in human leukemia cells, thereby controlling the proliferation and differentiation of leukemia cells. ABCC4 also enables COX deficient pancreatic cancer cells to obtain exogenous prostagladins. Researchers have shown that ABCC4 expression is elevated in drug resistant cancer cells, which makes it a potential target for cancer therapy . ABCC4 localizes to both plasma membrane and intracellular membranous structures. Investigators have also implicated ABCC4 in the pathogenesis of Kawasaki desease, a genetic childhood disease characterized by vasculitis. |
Synonyms: | ABCC4;EST170205; MOAT-B; MOATB; MRP4; |
UniProt Protein Function: | ABCC4: a widely-expressed multi-pass membrane protein. An organic anion pump involved in cellular detoxification. Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. |
UniProt Protein Details: | Protein type:Transporter; Membrane protein, multi-pass; Transporter, ABC family; Membrane protein, integral Chromosomal Location of Human Ortholog: 13q32 Cellular Component: membrane; basolateral plasma membrane; integral to membrane; plasma membrane; platelet dense granule membrane Molecular Function:ATPase activity, coupled to transmembrane movement of substances; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; ATP binding Biological Process: response to drug; platelet activation; platelet degranulation; positive regulation of smooth muscle cell proliferation; response to organic nitrogen; blood coagulation; transmembrane transport; response to organic cyclic substance |
NCBI Summary: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014] |
UniProt Code: | O15439 |
NCBI GenInfo Identifier: | 206729914 |
NCBI Gene ID: | 10257 |
NCBI Accession: | O15439.3 |
UniProt Related Accession: | O15439 |
Molecular Weight: | |
NCBI Full Name: | Multidrug resistance-associated protein 4 |
NCBI Synonym Full Names: | ATP binding cassette subfamily C member 4 |
NCBI Official Symbol: | ABCC4 |
NCBI Official Synonym Symbols: | MRP4; MOATB; MOAT-B |
NCBI Protein Information: | multidrug resistance-associated protein 4 |
UniProt Protein Name: | Multidrug resistance-associated protein 4 |
UniProt Synonym Protein Names: | ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B |
Protein Family: | ABC transporter C family |
UniProt Gene Name: | ABCC4 |
UniProt Entry Name: | MRP4_HUMAN |