ZPR1 Antibody (PACO20954)
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주문- SKU:
- PACO20954
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | ZPR1 Antibody (PACO20954) |
Antibody SKU: | PACO20954 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human ZPR1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20954(ZPR1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: Human liver cancer tissue, Primary antibody: PACO20954(ZPR1 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20954(ZPR1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | ZPR1 is a zinc finger-containing protein that is capable of binding to the intracellular tyrosine kinase domain of the epidermal growth factor receptor. Stimulation of mammalian cells with epidermal growth factor reduces ZPR1 affinity for the EGFR and leads to an accumulation of the protein in the nucleus. The ZPR1 zinc finger is necessary for its association with the EGFR. |
Synonyms: | ZPR1 zinc finger |
UniProt Protein Function: | ZNF259: May be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus. Binds to the EGF and PDGF receptors. Binds to the elongation factor 1-alpha EF1A. Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Belongs to the ZPR1 family. |
UniProt Protein Details: | Protein type:Nucleolus; Cell cycle regulation Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: nucleoplasm; Cajal body; growth cone; cell soma; perinuclear region of cytoplasm; axon; cytoplasm; nucleolus; perikaryon; SMN complex; nucleus Molecular Function:protein binding; zinc ion binding; translation initiation factor binding; receptor tyrosine kinase binding Biological Process: cell proliferation; regulation of myelination; trophectodermal cell proliferation; positive regulation of protein import into nucleus; spinal cord development; RNA splicing; DNA endoreduplication; Cajal body organization and biogenesis; microtubule cytoskeleton organization and biogenesis; mRNA processing; signal transduction; positive regulation of RNA splicing; positive regulation of growth; inner cell mass cell proliferation |
UniProt Code: | O75312 |
NCBI GenInfo Identifier: | 6137318 |
NCBI Gene ID: | 8882 |
NCBI Accession: | O75312.1 |
UniProt Secondary Accession: | O75312,Q2TAA0, |
UniProt Related Accession: | O75312 |
Molecular Weight: | 459 |
NCBI Full Name: | Zinc finger protein ZPR1 |
NCBI Synonym Full Names: | ZPR1 zinc finger |
NCBI Official Symbol: | ZPR1 |
NCBI Official Synonym Symbols: | ZNF259 |
NCBI Protein Information: | zinc finger protein ZPR1; zinc finger protein 259 |
UniProt Protein Name: | Zinc finger protein ZPR1 |
UniProt Synonym Protein Names: | Zinc finger protein 259 |
Protein Family: | Zinc finger protein |
UniProt Gene Name: | ZPR1 |
UniProt Entry Name: | ZPR1_HUMAN |
Antibodies |
Anti-ZPR1 Antibody (CAB15746) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |