ZNF281 Antibody (PACO20949)
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주문- SKU:
- PACO20949
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ZNF281 Antibody (PACO20949) |
Antibody SKU: | PACO20949 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human ZNF281 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using PACO20949(ZNF281 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20949(ZNF281 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | ZNF281, also known as GC-box-binding zinc finger protein 1, ZBP-99 or ZNP-99 (zinc finger DNA-binding protein 99), is a zinc finger protein that belongs to the Kr¼ppel C2H2-type zinc finger protein family. It is expressed ubiquitously at low levels with predominant expression in kidney, liver, lymphocytes and placenta. ZNF281 localizes to the nucleus and contains four C2H2-type zinc fingers. ZNF281 plays a role in repressing the transcription of a variety of genes including Gastrin and ODC (ornithine decarboxylase). In particular, ZNF281 functions by binding to the G-rich box in the enhancer region of the gene. Upon DNA damage, ZNF281 may become phosphorylated by Atm or ATR. |
Synonyms: | zinc finger protein 281 |
UniProt Protein Function: | ZNF281: Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin and ornithine decarboxylase. Binds to the G-rich box in the enhancer region of these genes. Belongs to the krueppel C2H2-type zinc-finger protein family. |
UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity Biological Process: embryonic body morphogenesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; stem cell differentiation |
UniProt Code: | Q9Y2X9 |
NCBI GenInfo Identifier: | 13124664 |
NCBI Gene ID: | 23528 |
NCBI Accession: | Q9Y2X9.1 |
UniProt Secondary Accession: | Q9Y2X9,Q5RKW5, Q9NY92, A6NF48, B3KMX2, |
UniProt Related Accession: | Q9Y2X9 |
Molecular Weight: | 93,232 Da |
NCBI Full Name: | Zinc finger protein 281 |
NCBI Synonym Full Names: | zinc finger protein 281 |
NCBI Official Symbol: | ZNF281 |
NCBI Official Synonym Symbols: | ZBP-99; ZNP-99 |
NCBI Protein Information: | zinc finger protein 281 |
UniProt Protein Name: | Zinc finger protein 281 |
UniProt Synonym Protein Names: | GC-box-binding zinc finger protein 1; Transcription factor ZBP-99; Zinc finger DNA-binding protein 99 |
Protein Family: | Zinc finger protein |
UniProt Gene Name: | ZNF281 |
UniProt Entry Name: | ZN281_HUMAN |
Antibodies |
Anti-ZNF281 Antibody (CAB12650) |
Secondary Antibody |
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