ZIC3 Antibody (PACO45306)
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주문- SKU:
- PACO45306
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ZIC3 Antibody (PACO45306) |
Antibody SKU: | PACO45306 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Zinc finger protein ZIC 3 protein (1-240AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO45306 at dilution of 1:100. |
Background: | Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. |
Synonyms: | Zinc finger protein ZIC 3 (Zinc finger protein 203) (Zinc finger protein of the cerebellum 3), ZIC3, ZNF203 |
UniProt Protein Function: | ZIC3: Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. Defects in ZIC3 are the cause of visceral heterotaxy X- linked type 1 (HTX1). A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy X- linked type 1 include dextrocardia, corrected transposition of great arteries, ventricular septal defect, patent ductus arteriosus, pulmonic stenosis, situs inversus viscerum, and asplenia and/or polysplenia. Defects in ZIC3 are a cause of VACTERL association X- linked with or without hydrocephalus (VACTERLX). A syndrome characterized by vertebral anomalies, anal atresia, cardiac malformations, tracheoesophageal fistula, renal anomalies (urethral atresia with hydronephrosis), and limb anomalies (hexadactyly, humeral hypoplasia, radial aplasia, and proximally placed thumb). Some patients may have hydrocephalus. Some cases of VACTERL-H are associated with increased chromosome breakage and rearrangement. Belongs to the GLI C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding; C2H2-type zinc finger protein; Transcription factor Chromosomal Location of Human Ortholog: Xq26.2 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: determination of left/right symmetry; heart looping; lung development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; somatic stem cell maintenance Disease: Heterotaxy, Visceral, 1, X-linked; Vacterl Association, X-linked, With Or Without Hydrocephalus |
NCBI Summary: | This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008] |
UniProt Code: | O60481 |
NCBI GenInfo Identifier: | 6137314 |
NCBI Gene ID: | 7547 |
NCBI Accession: | O60481.1 |
UniProt Secondary Accession: | O60481,Q14DE5, Q5JY75, B2CNW4, |
UniProt Related Accession: | O60481 |
Molecular Weight: | 50,045 Da |
NCBI Full Name: | Zinc finger protein ZIC 3 |
NCBI Synonym Full Names: | Zic family member 3 |
NCBI Official Symbol: | ZIC3 |
NCBI Official Synonym Symbols: | HTX; HTX1; ZNF203; VACTERLX |
NCBI Protein Information: | zinc finger protein ZIC 3 |
UniProt Protein Name: | Zinc finger protein ZIC 3 |
UniProt Synonym Protein Names: | Zinc finger protein 203; Zinc finger protein of the cerebellum 3 |
Protein Family: | Zinc finger protein |
UniProt Gene Name: | ZIC3 |
UniProt Entry Name: | ZIC3_HUMAN |
Antibodies |
Anti-ZIC3 Antibody (CAB9476) |
Secondary Antibody |
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