UniProt Protein Function: | YB-1: a nuclear protein that binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors CCAAT-containing Y-box of HLA class II genes. Component of cytoplasmic messenger ribonucleoprotein particles (mRNPs). Interacts with AKT1, SFRS9, THOC4, MSH2, XRCC5, WRN and NCL. Can bind to DNA as a homomeric form, (EFI-A)n or as a heteromeric form in association with EFI-B. Homodimer in the presence of ATP. Involved in cisplatin resistance. Seems to be a negative regulatory factor. May play a role in both transcriptional and translational regulation of spermatogenesis. Found at very low levels at day 10 and levels increase at day 15 and persist throughout adulthood. |
UniProt Protein Details: | Protein type:Transcription factor; RNA-binding; RNA splicing; RNA processing Chromosomal Location of Human Ortholog: 1p34 Cellular Component: nucleoplasm; nuclear membrane; intracellular membrane-bound organelle; stress granule; cytoplasm; nucleus; ribonucleoprotein complex; U12-dependent spliceosome Molecular Function:protein binding; DNA binding; RNA binding; double-stranded DNA binding; transcription factor activity; single-stranded DNA binding Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; negative regulation of striated muscle cell differentiation; regulation of transcription, DNA-dependent; in utero embryonic development; positive regulation of cell division; RNA splicing; positive regulation of transcription from RNA polymerase II promoter; gene expression; negative regulation of transcription from RNA polymerase II promoter |
UniProt Code: | P67809 |
NCBI GenInfo Identifier: | 34098946 |
NCBI Gene ID: | 4904 |
NCBI Accession: | NP_004550.2 |
UniProt Secondary Accession: | P67809,P16990, P16991, Q14972, Q15325, Q5FVF0, |
UniProt Related Accession: | P67809 |
Molecular Weight: | 35,924 Da |
NCBI Full Name: | nuclease-sensitive element-binding protein 1 |
NCBI Synonym Full Names: | Y box binding protein 1 |
NCBI Official Symbol: | YBX1 |
NCBI Official Synonym Symbols: | YB1; BP-8; CSDB; DBPB; YB-1; CSDA2; NSEP1; NSEP-1; MDR-NF1 |
NCBI Protein Information: | nuclease-sensitive element-binding protein 1; CBF-A; EFI-A; DNA-binding protein B; Y-box-binding protein 1; Y-box transcription factor; enhancer factor I subunit A; nuclease sensitive element binding protein 1; CCAAT-binding transcription factor I subunit |
UniProt Protein Name: | Nuclease-sensitive element-binding protein 1 |
UniProt Synonym Protein Names: | CCAAT-binding transcription factor I subunit A; CBF-A; DNA-binding protein B; DBPB; Enhancer factor I subunit A; EFI-A; Y-box transcription factor; Y-box-binding protein 1 |
Protein Family: | Nuclease-sensitive element-binding protein |
UniProt Gene Name: | YBX1 |
UniProt Entry Name: | YBOX1_HUMAN |