WNT10B Antibody (PACO20924)
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주문- SKU:
- PACO20924
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | WNT10B Antibody (PACO20924) |
Antibody SKU: | PACO20924 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:10-1:50 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human WNT10B |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: Hela cell, Primary antibody: PACO20924(WNT10B Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20924(WNT10B Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid, level. |
Synonyms: | wingless-type MMTV integration site family, member 10B |
UniProt Protein Function: | WNT10B: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Defects in WNT10B are the cause of split-hand/foot malformation type 6 (SHFM6). SHFM is a limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. SHFM6 is a autosomal recessive disorder. Belongs to the Wnt family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 12q13 Cellular Component: extracellular region; extracellular space Molecular Function:frizzled binding; receptor agonist activity Biological Process: cell fate commitment; chondrocyte differentiation; negative regulation of fat cell differentiation; neuron differentiation; positive regulation of apoptosis; protein stabilization; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin Disease: Split-hand/foot Malformation 6 |
NCBI Summary: | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008] |
UniProt Code: | O00744 |
NCBI GenInfo Identifier: | 20532419 |
NCBI Gene ID: | 7480 |
NCBI Accession: | O00744.2 |
UniProt Secondary Accession: | O00744,O00747, Q4VAJ4, Q4VAJ5, Q8WZ97, B2R7A5, |
UniProt Related Accession: | O00744 |
Molecular Weight: | 20,483 Da |
NCBI Full Name: | Protein Wnt-10b |
NCBI Synonym Full Names: | Wnt family member 10B |
NCBI Official Symbol: | WNT10B |
NCBI Official Synonym Symbols: | SHFM6; WNT-12 |
NCBI Protein Information: | protein Wnt-10b |
UniProt Protein Name: | Protein Wnt-10b |
UniProt Synonym Protein Names: | Protein Wnt-12 |
UniProt Gene Name: | WNT10B |
UniProt Entry Name: | WN10B_HUMAN |
Antibodies | ELISA Kits |
Anti-WNT10B Antibody (CAB16717) | Human WNT10B ELISA Kit |
Human Protein Wnt-10b (WNT10B) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |