WDR45 Antibody (PACO44716)
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주문- SKU:
- PACO44716
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | WDR45 Antibody (PACO44716) |
Antibody SKU: | PACO44716 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human WD repeat domain phosphoinositide-interacting protein 4 protein (1-360AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human liver tissue using PACO44716 at dilution of 1:100. |
Background: | Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. |
Synonyms: | WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45), WDR45, WDRX1 WDRXI4 WIPI4 |
UniProt Protein Function: | WDR45: a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008] |
UniProt Protein Details: | Protein type:Autophagy Chromosomal Location of Human Ortholog: Xp11.23 Cellular Component: cytosol; extrinsic to membrane; pre-autophagosomal structure membrane Molecular Function:phosphatidylinositol 3-phosphate binding Biological Process: autophagic vacuole formation; autophagy; mitochondrion degradation; protein amino acid lipidation Disease: Neurodegeneration With Brain Iron Accumulation 5 |
NCBI Summary: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y484 |
NCBI GenInfo Identifier: | 74762056 |
NCBI Gene ID: | 11152 |
NCBI Accession: | Q9Y484.1 |
UniProt Secondary Accession: | Q9Y484,Q5MNZ5, Q6IBS7, Q6NT94, Q96H03, A6NGH5, B7WPI2 |
UniProt Related Accession: | Q9Y484 |
Molecular Weight: | 39,939 Da |
NCBI Full Name: | WD repeat domain phosphoinositide-interacting protein 4 |
NCBI Synonym Full Names: | WD repeat domain 45 |
NCBI Official Symbol: | WDR45 |
NCBI Official Synonym Symbols: | JM5; NBIA4; NBIA5; WDRX1; WIPI4; WIPI-4 |
NCBI Protein Information: | WD repeat domain phosphoinositide-interacting protein 4 |
UniProt Protein Name: | WD repeat domain phosphoinositide-interacting protein 4 |
UniProt Synonym Protein Names: | WD repeat-containing protein 45 |
Protein Family: | WD repeat domain phosphoinositide-interacting protein |
UniProt Gene Name: | WDR45 |
UniProt Entry Name: | WIPI4_HUMAN |
Antibodies |
Anti-WDR45 Antibody (CAB7581) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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