WDR35 Antibody (PACO62819)
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주문- SKU:
- PACO62819
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | WDR35 Antibody (PACO62819) |
Antibody SKU: | PACO62819 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human WD repeat-containing protein 35 protein (954-1181AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO62819 diluted at 1:200 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis. |
Synonyms: | WD repeat-containing protein 35 (Intraflagellar transport protein 121 homolog), WDR35, IFT121 KIAA1336 |
UniProt Protein Function: | WDR35: a WD40 repeat protein. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. Two alternatively spliced human isoforms have been described. |
UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 2p24.1 Cellular Component: axoneme; centrosome; cilium Molecular Function:phosphoinositide binding Disease: Cranioectodermal Dysplasia 2; Short-rib Thoracic Dysplasia 7 With Or Without Polydactyly |
NCBI Summary: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010] |
UniProt Code: | Q9P2L0 |
NCBI GenInfo Identifier: | 48474987 |
NCBI Gene ID: | 57539 |
NCBI Accession: | Q9P2L0.3 |
UniProt Secondary Accession: | Q9P2L0,Q4ZG01, Q8NE11, B3KVI5, |
UniProt Related Accession: | Q9P2L0 |
Molecular Weight: | 134kDa |
NCBI Full Name: | WD repeat-containing protein 35 |
NCBI Synonym Full Names: | WD repeat domain 35 |
NCBI Official Symbol: | WDR35 |
NCBI Official Synonym Symbols: | CED2; IFTA1; SRTD7; IFT121 |
NCBI Protein Information: | WD repeat-containing protein 35 |
UniProt Protein Name: | WD repeat-containing protein 35 |
UniProt Synonym Protein Names: | Intraflagellar transport protein 121 homolog |
Protein Family: | WD repeat-containing protein |
UniProt Gene Name: | WDR35 |
Antibodies |
Anti-WDR35 Antibody (CAB12824) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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