VTCN1 Antibody (PACO17625)
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주문- SKU:
- PACO17625
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | VTCN1 Antibody (PACO17625) |
Antibody SKU: | PACO17625 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human VTCN1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17625(VTCN1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO17625(VTCN1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | V-set domain containing T cell activation inhibitor 1 |
UniProt Protein Function: | VTCN1: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1p13.1-p12 |
NCBI Summary: | This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q7Z7D3 |
NCBI GenInfo Identifier: | 74759262 |
NCBI Gene ID: | 79679 |
NCBI Accession: | Q7Z7D3.1 |
UniProt Secondary Accession: | Q7Z7D3,Q0GN76, Q45VN0, Q5WPZ3, Q6P097, Q9H6B2, |
UniProt Related Accession: | Q7Z7D3 |
Molecular Weight: | |
NCBI Full Name: | V-set domain-containing T-cell activation inhibitor 1 |
NCBI Synonym Full Names: | V-set domain containing T-cell activation inhibitor 1 |
NCBI Official Symbol: | VTCN1 |
NCBI Official Synonym Symbols: | B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291 |
NCBI Protein Information: | V-set domain-containing T-cell activation inhibitor 1 |
UniProt Protein Name: | V-set domain-containing T-cell activation inhibitor 1 |
UniProt Synonym Protein Names: | B7 homolog 4; B7-H4; B7h.5; Immune costimulatory protein B7-H4; Protein B7S1; T-cell costimulatory molecule B7x |
UniProt Gene Name: | VTCN1 |
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