VPS54 Antibody (PACO17436)
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주문- SKU:
- PACO17436
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | VPS54 Antibody (PACO17436) |
Antibody SKU: | PACO17436 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human VPS54 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17436(VPS54 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17436(VPS54 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes for a protein that in yeast forms part of a trimeric vacuolar-protein-sorting complex that is required for retrograde transport of proteins from prevacuoles to the late Golgi compartment. As in yeast, mammalian Vps54 proteins contain a coiled-coil region and dileucine motifs. Alternative splicing results in multiple transcript variants encoding different isoforms |
Synonyms: | vacuolar protein sorting 54 homolog (S. cerevisiae) |
UniProt Protein Function: | Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545). Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061). |
NCBI Summary: | This gene encodes for a protein that in yeast forms part of a trimeric vacuolar-protein-sorting complex that is required for retrograde transport of proteins from prevacuoles to the late Golgi compartment. As in yeast, mammalian Vps54 proteins contain a coiled-coil region and dileucine motifs. Alternative splicing results in multiple transcript variants encoding different isoforms [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9P1Q0 |
NCBI GenInfo Identifier: | 82583721 |
NCBI Gene ID: | 51542 |
NCBI Accession: | Q9P1Q0.2 |
UniProt Secondary Accession: | Q9P1Q0,Q5VIR5, Q86YF7, Q8N6G3, Q9NPV0, Q9NT07, Q9NUJ0 |
UniProt Related Accession: | Q9P1Q0 |
Molecular Weight: | 15,982 Da |
NCBI Full Name: | Vacuolar protein sorting-associated protein 54 |
NCBI Synonym Full Names: | VPS54, GARP complex subunit |
NCBI Official Symbol: | VPS54 |
NCBI Official Synonym Symbols: | WR; HCC8; SLP-8p; VPS54L; hVps54L; PPP1R164 |
NCBI Protein Information: | vacuolar protein sorting-associated protein 54 |
UniProt Protein Name: | Vacuolar protein sorting-associated protein 54 |
UniProt Synonym Protein Names: | Hepatocellular carcinoma protein 8; Tumor antigen HOM-HCC-8; Tumor antigen SLP-8p |
UniProt Gene Name: | VPS54 |
UniProt Entry Name: | VPS54_HUMAN |