VPS51 Antibody (PACO61734)
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주문- SKU:
- PACO61734
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | VPS51 Antibody (PACO61734) |
Antibody SKU: | PACO61734 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Vacuolar protein sorting-associated protein 51 homolog protein (595-673AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Hela whole cell lysate, U251 whole cell lysate, A549 whole cell lysate, U87 whole cell lysate. All lanes: VPS51 antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 87, 73 kDa. Observed band size: 87 kDa. |
Background: | Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid, hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid, hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. |
Synonyms: | Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog), VPS51, ANG2 C11orf2 C11orf3 FFR |
UniProt Protein Function: | Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). |
NCBI Summary: | This gene encodes a member of the vacuolar protein sorting-associated protein 51 family. The encoded protein is a component of the Golgi-associated retrograde protein complex which acts as a tethering factor for carriers in retrograde transport from the early and late endosomes to the trans-Golgi network. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] |
UniProt Code: | Q9UID3 |
NCBI GenInfo Identifier: | 8393009 |
NCBI Gene ID: | 738 |
NCBI Accession: | NP_037397.2 |
UniProt Secondary Accession: | Q9UID3,Q6PJV5, Q7L8A6, Q8WZ35, Q96DF4, Q96GR3, |
UniProt Related Accession: | Q9UID3 |
Molecular Weight: | 72,655 Da |
NCBI Full Name: | vacuolar protein sorting-associated protein 51 homolog |
NCBI Synonym Full Names: | VPS51, GARP complex subunit |
NCBI Official Symbol: | VPS51 |
NCBI Official Synonym Symbols: | FFR; ANG2; ANG3; C11orf2; C11orf3 |
NCBI Protein Information: | vacuolar protein sorting-associated protein 51 homolog |
UniProt Protein Name: | Vacuolar protein sorting-associated protein 51 homolog |
UniProt Synonym Protein Names: | Another new gene 2 protein; Protein fat-free homolog |
UniProt Gene Name: | VPS51 |
Antibodies | ELISA Kits |
Anti-VPS51 Antibody (CAB15651) | Human Angiopoietin 2 ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |