USP3 Antibody (PACO42710)
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주문- SKU:
- PACO42710
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | USP3 Antibody (PACO42710) |
Antibody SKU: | PACO42710 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Ubiquitin carboxyl-terminal hydrolase 3 protein (201-500AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO42710 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO42710 at dilution of 1:100. |
Background: | Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin. |
Synonyms: | Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3), USP3 |
UniProt Protein Function: | USP3: Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin. Belongs to the peptidase C19 family. USP3 subfamily. |
UniProt Protein Details: | Protein type:Protease; Ubiquitin-specific protease; EC 3.4.19.12; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 15q22.3 Cellular Component: nuclear chromatin Molecular Function:zinc ion binding; histone binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity; chromatin binding Biological Process: proteasomal ubiquitin-dependent protein catabolic process; regulation of transcription, DNA-dependent; regulation of protein stability; mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; DNA repair; histone deubiquitination |
UniProt Code: | Q9Y6I4 |
NCBI GenInfo Identifier: | 205371844 |
NCBI Gene ID: | 9960 |
NCBI Accession: | Q9Y6I4.2 |
UniProt Related Accession: | Q9Y6I4 |
Molecular Weight: | Calculated: 53kDa; 58kDaObserved: 67kDa |
NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 3 |
NCBI Synonym Full Names: | ubiquitin specific peptidase 3 |
NCBI Official Symbol: | USP3 |
NCBI Official Synonym Symbols: | UBP; SIH003 |
NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 3 |
UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 3 |
UniProt Synonym Protein Names: | Deubiquitinating enzyme 3; Ubiquitin thioesterase 3; Ubiquitin-specific-processing protease 3 |
UniProt Gene Name: | USP3 |
UniProt Entry Name: | UBP3_HUMAN |