USP13 Antibody (PACO05651)
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주문- SKU:
- PACO05651
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | USP13 Antibody (PACO05651) |
Antibody SKU: | PACO05651 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:40000, WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from the C-terminal region of human USP13. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | USP13; ISOT3; Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinating enzyme 13; Isopeptidase T-3; ISOT-3; Ubiquitin thioesterase 13; Ubiquitin-specific-processing protease 13 |
UniProt Protein Function: | USP13: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data. Belongs to the peptidase C19 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Chromosomal Location of Human Ortholog: 3q26.33 Cellular Component: cytosol; nucleoplasm Molecular Function:chaperone binding; cysteine-type endopeptidase activity; protein binding; ubiquitin binding; ubiquitin protein ligase binding; ubiquitin-specific protease activity Biological Process: cell proliferation; melanocyte differentiation; protein deubiquitination; protein stabilization; regulation of autophagy; regulation of transcription, DNA-dependent |
UniProt Code: | Q92995 |
NCBI GenInfo Identifier: | 209572692 |
NCBI Gene ID: | 8975 |
NCBI Accession: | Q92995.2 |
UniProt Secondary Accession: | Q92995,Q96B25, A8K2S3, B4DYF3, D3DNS2, |
UniProt Related Accession: | Q92995 |
Molecular Weight: | 97kDa |
NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 13 |
NCBI Synonym Full Names: | ubiquitin specific peptidase 13 (isopeptidase T-3) |
NCBI Official Symbol: | USP13 |
NCBI Official Synonym Symbols: | ISOT3; IsoT-3 |
NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 13 |
UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 13 |
UniProt Synonym Protein Names: | Deubiquitinating enzyme 13; Isopeptidase T-3; ISOT-3; Ubiquitin thioesterase 13; Ubiquitin-specific-processing protease 13 |
UniProt Gene Name: | USP13 |