UBE2W Antibody (PACO13043)
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주문- SKU:
- PACO13043
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | UBE2W Antibody (PACO13043) |
Antibody SKU: | PACO13043 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human UBE2W |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | ubiquitin-conjugating enzyme E2W (putative);UBE2W;FLJ11011;hUBC-16 ; |
UniProt Protein Function: | UBE2W: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Belongs to the ubiquitin-conjugating enzyme family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19; Enzyme, misc.; Ligase Chromosomal Location of Human Ortholog: 8q21.11 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity Biological Process: misfolded or incompletely synthesized protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; protein monoubiquitination |
NCBI Summary: | This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
UniProt Code: | Q96B02 |
NCBI GenInfo Identifier: | 74751754 |
NCBI Gene ID: | 55284 |
NCBI Accession: | Q96B02.1 |
UniProt Secondary Accession: | Q96B02,Q1XBE0, Q9H823, Q9HAG6, Q9NV07, B4DIV1, |
UniProt Related Accession: | Q96B02 |
Molecular Weight: | 20,689 Da |
NCBI Full Name: | Ubiquitin-conjugating enzyme E2 W |
NCBI Synonym Full Names: | ubiquitin conjugating enzyme E2 W (putative) |
NCBI Official Symbol: | UBE2W |
NCBI Official Synonym Symbols: | UBC16; UBC-16 |
NCBI Protein Information: | ubiquitin-conjugating enzyme E2 W |
UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 W |
UniProt Synonym Protein Names: | E2 ubiquitin-conjugating enzyme W; N-terminal E2 ubiquitin-conjugating enzyme (EC:2.3.2.25 |
Protein Family: | Ubiquitin-conjugating enzyme |
UniProt Gene Name: | UBE2W |
UniProt Entry Name: | UBE2W_HUMAN |