UBE2T Antibody (PACO22680)
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주문- SKU:
- PACO22680
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | UBE2T Antibody (PACO22680) |
Antibody SKU: | PACO22680 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from internal of human UBE2T. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from HeLa cells, Jurkat cells and K562 cells, using UBE2T antibody. |
Background: | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. |
Synonyms: | Ubiquitin-conjugating enzyme E2 T; Ubiquitin-protein ligase T; Ubiquitin carrier protein T; UBE2T; |
UniProt Protein Function: | UBE2T: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Belongs to the ubiquitin-conjugating enzyme family. |
UniProt Protein Details: | Protein type:Ubiquitin ligase; EC 6.3.2.19; Ligase; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; chromatin binding; ATP binding; ligase activity Biological Process: protein monoubiquitination; protein autoubiquitination; DNA repair; response to DNA damage stimulus Disease: Fanconi Anemia, Complementation Group T |
NCBI Summary: | The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006 [PubMed 16916645]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q9NPD8 |
NCBI GenInfo Identifier: | 73622065 |
NCBI Gene ID: | 29089 |
NCBI Accession: | Q9NPD8.1 |
UniProt Secondary Accession: | Q9NPD8,Q2TU36, |
UniProt Related Accession: | Q9NPD8 |
Molecular Weight: | 197 |
NCBI Full Name: | Ubiquitin-conjugating enzyme E2 T |
NCBI Synonym Full Names: | ubiquitin-conjugating enzyme E2T |
NCBI Official Symbol: | UBE2T |
NCBI Official Synonym Symbols: | PIG50; HSPC150 |
NCBI Protein Information: | ubiquitin-conjugating enzyme E2 T; ubiquitin-protein ligase T; ubiquitin carrier protein T; ubiquitin conjugating enzyme; cell proliferation-inducing gene 50 protein; ubiquitin-conjugating enzyme E2T (putative); HSPC150 protein similar to ubiquitin-conjugating enzyme |
UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 T |
UniProt Synonym Protein Names: | Cell proliferation-inducing gene 50 protein; Ubiquitin carrier protein T; Ubiquitin-protein ligase T |
Protein Family: | Ubiquitin-conjugating enzyme |
UniProt Gene Name: | UBE2T |
UniProt Entry Name: | UBE2T_HUMAN |