UBA6 Antibody (PACO47734)
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주문- SKU:
- PACO47734
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | UBA6 Antibody (PACO47734) |
Antibody SKU: | PACO47734 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Ubiquitin-like modifier-activating enzyme 6 protein (1-44AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO47734 at dilution of 1:100. | |
Immunofluorescent analysis of Hela cells using PACO47734 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO47734 at dilution of 1:100. |
Background: | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. |
Synonyms: | Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2), UBA6, MOP4 UBE1L2 |
UniProt Protein Function: | UBE1L2: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. Belongs to the ubiquitin-activating E1 family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin ligase; EC 6.3.2.19; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 4q13.2 Cellular Component: cytoplasm; cytosol Molecular Function:protein binding; FAT10 activating enzyme activity; ATP binding Biological Process: ubiquitin-dependent protein catabolic process; protein ubiquitination |
NCBI Summary: | Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008] |
UniProt Code: | A0AVT1 |
NCBI GenInfo Identifier: | 121949450 |
NCBI Gene ID: | 55236 |
NCBI Accession: | A0AVT1.1 |
UniProt Related Accession: | A0AVT1 |
Molecular Weight: | |
NCBI Full Name: | Ubiquitin-like modifier-activating enzyme 6 |
NCBI Synonym Full Names: | ubiquitin like modifier activating enzyme 6 |
NCBI Official Symbol: | UBA6 |
NCBI Official Synonym Symbols: | E1-L2; MOP-4; UBE1L2 |
NCBI Protein Information: | ubiquitin-like modifier-activating enzyme 6 |
UniProt Protein Name: | Ubiquitin-like modifier-activating enzyme 6 |
UniProt Synonym Protein Names: | Monocyte protein 4; MOP-4; Ubiquitin-activating enzyme E1-like protein 2; E1-L2 |
Protein Family: | Ubiquitin-like modifier-activating enzyme |
UniProt Gene Name: | UBA6 |
UniProt Entry Name: | UBA6_HUMAN |