UniProt Protein Function: | UBA3: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. Belongs to the ubiquitin-activating E1 family. UBA3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; EC 6.3.2.19; Ubiquitin ligase; Ligase; Ubiquitin conjugating system; Cell cycle regulation; EC 6.3.2.- Chromosomal Location of Human Ortholog: 3p14.1 Cellular Component: nucleus; cytosol Molecular Function:NEDD8 activating enzyme activity; protein binding; acid-amino acid ligase activity; protein heterodimerization activity; ATP binding Biological Process: protein neddylation; regulation of cell cycle; protein modification process; endomitotic cell cycle; proteolysis |
NCBI Summary: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8TBC4 |
NCBI GenInfo Identifier: | 83305811 |
NCBI Gene ID: | 9039 |
NCBI Accession: | Q8TBC4.2 |
UniProt Related Accession: | Q8TBC4 |
Molecular Weight: | |
NCBI Full Name: | NEDD8-activating enzyme E1 catalytic subunit |
NCBI Synonym Full Names: | ubiquitin like modifier activating enzyme 3 |
NCBI Official Symbol: | UBA3 |
NCBI Official Synonym Symbols: | NAE2; UBE1C; hUBA3 |
NCBI Protein Information: | NEDD8-activating enzyme E1 catalytic subunit |
UniProt Protein Name: | NEDD8-activating enzyme E1 catalytic subunit |
UniProt Synonym Protein Names: | NEDD8-activating enzyme E1C; Ubiquitin-activating enzyme E1C; Ubiquitin-like modifier-activating enzyme 3; Ubiquitin-activating enzyme 3 |
Protein Family: | Ubiquitin-activating enzyme |
UniProt Gene Name: | UBA3 |
UniProt Entry Name: | UBA3_HUMAN |