UACA Antibody (PACO45589)
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주문- SKU:
- PACO45589
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | UACA Antibody (PACO45589) |
Antibody SKU: | PACO45589 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (1-90AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: UACA antibody at 5.51µg/ml. Lane 1: Hela whole cell lysate. Lane 2: A549 whole cell lysate. Lane 3: Jurkat whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 163, 162 kDa. Observed band size: 163, 140 kDa.. | |
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO45589 at dilution of 1:100. |
Background: | Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). |
Synonyms: | Uveal autoantigen with coiled-coil domains and ankyrin repeats, UACA, KIAA1561 |
UniProt Protein Function: | UACA: Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1. |
UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 15q22-q24 Cellular Component: nucleoplasm; cytoskeleton; membrane; mitochondrion; perinuclear region of cytoplasm; cytoplasm; extracellular region; nuclear envelope; nucleus; apoptosome Molecular Function:protein binding Biological Process: positive regulation of protein import into nucleus; DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of inflammatory response; positive regulation of caspase activity; negative regulation of NF-kappaB import into nucleus; induction of apoptosis by oxidative stress; response to UV |
UniProt Code: | Q9BZF9 |
NCBI GenInfo Identifier: | 56550047 |
NCBI Gene ID: | 55075 |
NCBI Accession: | NP_001008225.1 |
UniProt Secondary Accession: | Q9BZF9,Q14DD3, Q8N3B8, Q96NH6, Q9HCL1, Q9NWC6, G3XAG2 |
UniProt Related Accession: | Q9BZF9 |
Molecular Weight: | 162,505 Da |
NCBI Full Name: | uveal autoantigen with coiled-coil domains and ankyrin repeats isoform 2 |
NCBI Synonym Full Names: | uveal autoantigen with coiled-coil domains and ankyrin repeats |
NCBI Official Symbol: | UACA |
NCBI Official Synonym Symbols: | NUCLING |
NCBI Protein Information: | uveal autoantigen with coiled-coil domains and ankyrin repeats; nuclear membrane binding protein; uveal autoantigen with coiled coil domains and ankyrin repeats |
UniProt Protein Name: | Uveal autoantigen with coiled-coil domains and ankyrin repeats |
Protein Family: | Uveal autoantigen with coiled-coil domains and ankyrin repeats |
UniProt Gene Name: | UACA |
UniProt Entry Name: | UACA_HUMAN |
Antibodies | ELISA Kits |
Anti-UACA Antibody (CAB9713) | Human UACA ELISA Kit |
Human Uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |