U2AF1L4 Antibody (PACO44565)
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주문- SKU:
- PACO44565
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | U2AF1L4 Antibody (PACO44565) |
Antibody SKU: | PACO44565 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Splicing factor U2AF 26 kDa subunit protein (1-202AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO44565 at dilution of 1:100. |
Background: | RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). |
Synonyms: | Splicing factor U2AF 26 kDa subunit (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) (U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3) (U2 small nuclear RNA auxiliary factor 1-like protein 3) (U2AF1-like protein 3), U2AF1L4, U2AF1-RS3 U2AF1L3 |
UniProt Protein Function: | U2AF1L4: RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site. Belongs to the splicing factor SR family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:RNA splicing Chromosomal Location of Human Ortholog: 19q13.12 Cellular Component: spliceosome; cytoplasm; nuclear speck Molecular Function:RNA binding; metal ion binding; nucleotide binding Biological Process: RNA splicing; mRNA processing |
UniProt Code: | Q8WU68 |
NCBI GenInfo Identifier: | 160358766 |
NCBI Gene ID: | 199746 |
NCBI Accession: | Q8WU68.2 |
UniProt Secondary Accession: | Q8WU68,Q56UU3, A6NKI8, |
UniProt Related Accession: | Q8WU68 |
Molecular Weight: | 220 |
NCBI Full Name: | Splicing factor U2AF 26 kDa subunit |
NCBI Synonym Full Names: | U2 small nuclear RNA auxiliary factor 1-like 4 |
NCBI Official Symbol: | U2AF1L4 |
NCBI Official Synonym Symbols: | U2af26; U2AF1L3; U2AF1RS3; U2AF1-RS3; U2AF1L3V1 |
NCBI Protein Information: | splicing factor U2AF 26 kDa subunit; U2AF1-like 4; U2AF1-like protein 3; U2 auxiliary factor 26; U2 small nuclear RNA auxiliary factor 1-like 3; U2(RNU2) small nuclear RNA auxiliary factor 1-like 3; U2 small nuclear RNA auxiliary factor 1-like protein 3; U2 small nuclear RNA auxiliary factor 1-like protein 4; U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3 |
UniProt Protein Name: | Splicing factor U2AF 26 kDa subunit |
UniProt Synonym Protein Names: | U2 auxiliary factor 26U2 small nuclear RNA auxiliary factor 1-like protein 4 |
Protein Family: | Splicing factor |
UniProt Gene Name: | U2AF1L4 |
UniProt Entry Name: | U2AF4_HUMAN |
Antibodies |
Anti-U2AF1L4 Antibody (CAB7151) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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