TYK2 Antibody (PACO52030)
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주문- SKU:
- PACO52030
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | TYK2 Antibody (PACO52030) |
Antibody SKU: | PACO52030 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Non-receptor tyrosine-protein kinase TYK2 protein (286-372AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO52030 at dilution of 1:100. | |
Immunofluorescent analysis of A549 cells using PACO52030 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/β receptor α chain. |
Synonyms: | Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2), TYK2 |
UniProt Protein Function: | Tyk2: a non-receptor tyrosine-protein kinase of the JakA family. Activated in signaling from the IL-2, gp130 and IFN families of receptors. Phosphorylates the interferon-alpha/beta receptor alpha chain. |
UniProt Protein Details: | Protein type:Protein kinase, TK; EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; JakA family Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; cytoplasm; nucleus; cytosol Molecular Function:protein binding; growth hormone receptor binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; type 1 angiotensin receptor binding; ATP binding Biological Process: cell migration; cytokine and chemokine mediated signaling pathway; innate immune response; cell differentiation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation Disease: Immunodeficiency 35 |
NCBI Summary: | This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008] |
UniProt Code: | P29597 |
NCBI GenInfo Identifier: | 56405328 |
NCBI Gene ID: | 7297 |
NCBI Accession: | P29597.3 |
UniProt Secondary Accession: | P29597,Q6QB10, Q96CH0, |
UniProt Related Accession: | P29597 |
Molecular Weight: | 1187 |
NCBI Full Name: | Non-receptor tyrosine-protein kinase TYK2 |
NCBI Synonym Full Names: | tyrosine kinase 2 |
NCBI Official Symbol: | TYK2 |
NCBI Official Synonym Symbols: | JTK1; IMD35 |
NCBI Protein Information: | non-receptor tyrosine-protein kinase TYK2 |
UniProt Protein Name: | Non-receptor tyrosine-protein kinase TYK2 |
Protein Family: | Non-receptor tyrosine-protein kinase |
UniProt Gene Name: | TYK2 |
UniProt Entry Name: | TYK2_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |