TTK Antibody (PACO12977)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO12977
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TTK Antibody (PACO12977) |
Antibody SKU: | PACO12977 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human TTK |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.320°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | 97kd; |
UniProt Protein Function: | TTK: a dual-specificity protein kinase orthologous to the yeast monopolar spindle (Mps1) kinase that is required for spindle pole duplication and the spindle checkpoint but not for centrosome duplication. Localized to centrosomes, kinetochores and nuclear pores. Its enzymatic activity is required for the recruitment of Mad1, Mad2, Bub1 and Bub3 to the kinetochore. Mps1 mRNA levels change little throughout the cell cycle, but its protein expression varies during the cell cycle. Overexpression arrests cells in metaphase by activating the checkpoint. |
UniProt Protein Details: | Protein type:Protein kinase, Other; Kinase, protein; Protein kinase, dual-specificity (non-receptor); EC 2.7.12.1; Cancer Testis Antigen (CTA); Other group; TTK family Chromosomal Location of Human Ortholog: 6q14.1 Cellular Component: membrane; spindle Molecular Function:protein binding Biological Process: mitotic cell cycle spindle assembly checkpoint; mitotic spindle organization and biogenesis; positive regulation of cell proliferation; spindle organization and biogenesis |
NCBI Summary: | This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009] |
UniProt Code: | P33981 |
NCBI GenInfo Identifier: | 160112977 |
NCBI Gene ID: | 7272 |
NCBI Accession: | P33981.2 |
UniProt Secondary Accession: | P33981,Q15272, Q5TCS0, Q9BW51, Q9NTM0, A8K8U5, B2RDW2 E1P543, |
UniProt Related Accession: | P33981 |
Molecular Weight: | 96,944 Da |
NCBI Full Name: | Dual specificity protein kinase TTK |
NCBI Synonym Full Names: | TTK protein kinase |
NCBI Official Symbol: | TTK |
NCBI Official Synonym Symbols: | ESK; PYT; CT96; MPH1; MPS1; MPS1L1 |
NCBI Protein Information: | dual specificity protein kinase TTK |
UniProt Protein Name: | Dual specificity protein kinase TTK |
UniProt Synonym Protein Names: | Phosphotyrosine picked threonine-protein kinase; PYT |
Protein Family: | Protein tramtrack |
UniProt Gene Name: | TTK |
UniProt Entry Name: | TTK_HUMAN |