UniProt Protein Function: | TSPYL2: Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. Belongs to the nucleosome assembly protein (NAP) family. |
UniProt Protein Details: | Protein type:Transcription regulation; DNA replication Chromosomal Location of Human Ortholog: Xp11.2 Cellular Component: centrosome; cytoplasm; nucleolus; nucleoplasm; nucleus; plasma membrane Biological Process: negative regulation of cell growth; negative regulation of DNA replication; regulation of protein kinase activity |
NCBI Summary: | This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009] |
UniProt Code: | Q9H2G4 |
NCBI GenInfo Identifier: | 74752604 |
NCBI Gene ID: | 64061 |
NCBI Accession: | Q9H2G4.1 |
UniProt Secondary Accession: | Q9H2G4,O94799, Q96DG7, Q9BZW6, |
UniProt Related Accession: | Q9H2G4 |
Molecular Weight: | 79,435 Da |
NCBI Full Name: | Testis-specific Y-encoded-like protein 2 |
NCBI Synonym Full Names: | TSPY like 2 |
NCBI Official Symbol: | TSPYL2 |
NCBI Official Synonym Symbols: | CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216 |
NCBI Protein Information: | testis-specific Y-encoded-like protein 2 |
UniProt Protein Name: | Testis-specific Y-encoded-like protein 2 |
UniProt Synonym Protein Names: | Cell division autoantigen 1; Cutaneous T-cell lymphoma-associated antigen se20-4; CTCL-associated antigen se20-4; Differentially-expressed nucleolar TGF-beta1 target protein; Nuclear protein of 79 kDa; NP79 |
Protein Family: | Testis-specific Y-encoded-like protein |
UniProt Gene Name: | TSPYL2 |
UniProt Entry Name: | TSYL2_HUMAN |