TRIM23 Antibody (PACO45210)
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주문- SKU:
- PACO45210
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TRIM23 Antibody (PACO45210) |
Antibody SKU: | PACO45210 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human E3 ubiquitin-protein ligase TRIM23 protein (1-280AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: TRIM23 antibody at 2.67 µg/ml + Raw264.7 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 65, 64, 62 kDa. Observed band size: 65 kDa.. | |
Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO45210 at dilution of 1:100. |
Background: | Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit. |
Synonyms: | E3 ubiquitin-protein ligase TRIM23 (EC 2.3.2.27) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (RING-type E3 ubiquitin transferase TRIM23) (Tripartite motif-containing protein 23), TRIM23, ARD1 ARFD1 RNF46 |
UniProt Protein Function: | TRIM23: Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ubiquitin ligase; Ligase; EC 6.3.2.- Chromosomal Location of Human Ortholog: 5q12.3 Cellular Component: Golgi membrane; lysosomal membrane Molecular Function:enzyme activator activity; GDP binding; GTP binding; GTPase activity; identical protein binding; protein binding; ubiquitin-protein ligase activity Biological Process: protein ubiquitination |
NCBI Summary: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008] |
UniProt Code: | P36406 |
NCBI GenInfo Identifier: | 543839 |
NCBI Gene ID: | 373 |
NCBI Accession: | P36406.1 |
UniProt Secondary Accession: | P36406,Q9BZY4, Q9BZY5, |
UniProt Related Accession: | P36406 |
Molecular Weight: | 61,068 Da |
NCBI Full Name: | E3 ubiquitin-protein ligase TRIM23 |
NCBI Synonym Full Names: | tripartite motif containing 23 |
NCBI Official Symbol: | TRIM23 |
NCBI Official Synonym Symbols: | ARD1; ARFD1; RNF46 |
NCBI Protein Information: | E3 ubiquitin-protein ligase TRIM23 |
UniProt Protein Name: | E3 ubiquitin-protein ligase TRIM23 |
UniProt Synonym Protein Names: | ADP-ribosylation factor domain-containing protein 1; GTP-binding protein ARD-1; RING finger protein 46; Tripartite motif-containing protein 23 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | TRIM23 |
UniProt Entry Name: | TRI23_HUMAN |