TRAF3IP2 Antibody (PACO42907)
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주문- SKU:
- PACO42907
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TRAF3IP2 Antibody (PACO42907) |
Antibody SKU: | PACO42907 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Adapter protein CIKS protein (1-300AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO42907 at dilution of 1:100. |
Background: | Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK. |
Synonyms: | Adapter protein CIKS (Connection to IKK and SAPK/JNK) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2), TRAF3IP2, C6orf2 C6orf4 C6orf5 C6orf6 |
UniProt Protein Function: | TRAF3IP2: Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK. Defects in TRAF3IP2 are the cause of susceptibility to psoriasis type 13 (PSORS13). PSORS13 is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 6q21 Cellular Component: intracellular Molecular Function:protein binding; receptor binding Biological Process: B cell apoptosis; humoral immune response; immunoglobulin secretion; positive regulation of defense response to virus by host; positive regulation of I-kappaB kinase/NF-kappaB cascade Disease: Candidiasis, Familial, 8; Psoriasis 13, Susceptibility To |
NCBI Summary: | This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009] |
UniProt Code: | O43734 |
NCBI GenInfo Identifier: | 317373453 |
NCBI Gene ID: | 10758 |
NCBI Accession: | O43734.3 |
UniProt Secondary Accession: | O43734,Q5R3A3, Q7Z6Q1, Q7Z6Q2, Q7Z6Q3, Q9H5W2, Q9H6Y3 Q9NS14, Q9UG72, B2RAY9, E1P555, |
UniProt Related Accession: | O43734 |
Molecular Weight: | 63,457 Da |
NCBI Full Name: | Adapter protein CIKS |
NCBI Synonym Full Names: | TRAF3 interacting protein 2 |
NCBI Official Symbol: | TRAF3IP2 |
NCBI Official Synonym Symbols: | ACT1; CIKS; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; PSORS13 |
NCBI Protein Information: | adapter protein CIKS |
UniProt Protein Name: | Adapter protein CIKS |
UniProt Synonym Protein Names: | Connection to IKK and SAPK/JNK; Nuclear factor NF-kappa-B activator 1; ACT1; TRAF3-interacting protein 2 |
UniProt Gene Name: | TRAF3IP2 |
UniProt Entry Name: | CIKS_HUMAN |
Antibodies |
Anti-TRAF3IP2 Antibody (CAB6776) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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