TPH2 Antibody (PACO20742)
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주문- SKU:
- PACO20742
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TPH2 Antibody (PACO20742) |
Antibody SKU: | PACO20742 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:10-1:50 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human TPH2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20742(TPH2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: Huvec cells, Primary antibody: PACO20742(TPH2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. | |
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20742(TPH2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of the pterin-dependent aromatic acid, hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. |
Synonyms: | tryptophan hydroxylase 2 |
UniProt Protein Function: | TPH2: an enzyme that is rate-limiting in the biosynthesis of serotonin. It catalyzes the biopterin dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. Its expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells. Two alternatively spliced isoforms have been described. Isoform 2 appears to be expressed exclusively in the brain, and is expressed at significantly higher levels in the raphe nuclei than isoform 1. |
UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.14.16.4; Amino Acid Metabolism - tryptophan Chromosomal Location of Human Ortholog: 12q21.1 Cellular Component: cytosol Biological Process: indolalkylamine biosynthetic process Disease: Attention Deficit-hyperactivity Disorder, Susceptibility To, 7; Major Depressive Disorder |
NCBI Summary: | This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016] |
UniProt Code: | Q8IWU9 |
NCBI GenInfo Identifier: | 30580625 |
NCBI Gene ID: | 121278 |
NCBI Accession: | Q8IWU9.1 |
UniProt Secondary Accession: | Q8IWU9,Q14CB0, A6NGA4, |
UniProt Related Accession: | Q8IWU9 |
Molecular Weight: | 56,242 Da |
NCBI Full Name: | Tryptophan 5-hydroxylase 2 |
NCBI Synonym Full Names: | tryptophan hydroxylase 2 |
NCBI Official Symbol: | TPH2 |
NCBI Official Synonym Symbols: | NTPH; ADHD7 |
NCBI Protein Information: | tryptophan 5-hydroxylase 2 |
UniProt Protein Name: | Tryptophan 5-hydroxylase 2 |
UniProt Synonym Protein Names: | Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2 |
Protein Family: | Tryptophan 5-hydroxylase |
UniProt Gene Name: | TPH2 |
UniProt Entry Name: | TPH2_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |