UniProt Protein Function: | TP53I3: May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro). Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 1.-.-.-; Oxidoreductase Chromosomal Location of Human Ortholog: 2p23.3 Molecular Function:NADPH:quinone reductase activity; protein homodimerization activity; quinone binding; zinc ion binding Biological Process: NADP metabolic process |
NCBI Summary: | The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] |
UniProt Code: | Q53FA7 |
NCBI GenInfo Identifier: | 76789665 |
NCBI Gene ID: | 9540 |
NCBI Accession: | Q53FA7.2 |
UniProt Secondary Accession: | Q53FA7,O14679, O14685, Q38G78, Q6JLE7, Q9BWB8, D6W533 |
UniProt Related Accession: | Q53FA7 |
Molecular Weight: | 25,402 Da |
NCBI Full Name: | Quinone oxidoreductase PIG3 |
NCBI Synonym Full Names: | tumor protein p53 inducible protein 3 |
NCBI Official Symbol: | TP53I3 |
NCBI Official Synonym Symbols: | PIG3 |
NCBI Protein Information: | quinone oxidoreductase PIG3 |
UniProt Protein Name: | Quinone oxidoreductase PIG3 |
UniProt Synonym Protein Names: | Tumor protein p53-inducible protein 3; p53-induced gene 3 protein |
Protein Family: | Quinone oxidoreductase |
UniProt Gene Name: | TP53I3 |
UniProt Entry Name: | QORX_HUMAN |