TP53BP2 Antibody (PACO17616)
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주문- SKU:
- PACO17616
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TP53BP2 Antibody (PACO17616) |
Antibody SKU: | PACO17616 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:5-1:20 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human TP53BP2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO17616(TP53BP2 Antibody) at dilution 1/5, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO17616(TP53BP2 Antibody) at dilution 1/5, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | tumor protein p53 binding protein, 2 |
UniProt Protein Function: | 53BP2: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. Belongs to the ASPP family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1q41 Cellular Component: cytoplasm; nucleoplasm; nucleus; perinuclear region of cytoplasm Molecular Function:identical protein binding; NF-kappaB binding; p53 binding; protein binding; SH3/SH2 adaptor activity Biological Process: negative regulation of cell cycle; regulation of apoptosis; signal transduction |
NCBI Summary: | This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13625 |
NCBI GenInfo Identifier: | 33860140 |
NCBI Gene ID: | 7159 |
NCBI Accession: | Q13625.2 |
UniProt Secondary Accession: | Q13625,Q12892, Q86X75, Q96KQ3, B4DG66, |
UniProt Related Accession: | Q13625 |
Molecular Weight: | 126,323 Da |
NCBI Full Name: | Apoptosis-stimulating of p53 protein 2 |
NCBI Synonym Full Names: | tumor protein p53 binding protein 2 |
NCBI Official Symbol: | TP53BP2 |
NCBI Official Synonym Symbols: | BBP; 53BP2; ASPP2; P53BP2; PPP1R13A |
NCBI Protein Information: | apoptosis-stimulating of p53 protein 2 |
UniProt Protein Name: | Apoptosis-stimulating of p53 protein 2 |
UniProt Synonym Protein Names: | Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2; 53BP2; p53-binding protein 2; p53BP2 |
Protein Family: | Apoptosis-stimulating of p53 protein |
UniProt Gene Name: | TP53BP2 |
UniProt Entry Name: | ASPP2_HUMAN |