TNK1 Antibody (PACO20731)
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주문- SKU:
- PACO20731
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TNK1 Antibody (PACO20731) |
Antibody SKU: | PACO20731 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:20-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human TNK1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: Human fetal brain tissue, Primary antibody: PACO20731(TNK1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20731(TNK1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. |
Synonyms: | tyrosine kinase, non-receptor, 1 |
UniProt Protein Function: | TNK1: Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. Interacts with the SH3 domain of PLCG1 via its Pro-rich domain. Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. Belongs to the protein kinase superfamily. Tyr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 2.7.10.2; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Kinase, protein; TK group; Ack familyChromosomal Location of Human Ortholog: 17p13.1Cellular Component: cytoplasm; extrinsic to internal side of plasma membrane; membraneMolecular Function: ATP binding; protein binding; protein-tyrosine kinase activity; receptor binding; signal transducer activityBiological Process: cell differentiation; innate immune response; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
UniProt Code: | Q13470 |
NCBI GenInfo Identifier: | 116242821 |
NCBI Gene ID: | 8711 |
NCBI Accession: | Q13470.3 |
UniProt Secondary Accession: | Q13470,O95364, Q8IYI4 |
UniProt Related Accession: | Q13470 |
Molecular Weight: | 71,922 Da |
NCBI Full Name: | Non-receptor tyrosine-protein kinase TNK1 |
NCBI Synonym Full Names: | tyrosine kinase non receptor 1 |
NCBI Official Symbol: | TNK1 |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | non-receptor tyrosine-protein kinase TNK1 |
UniProt Protein Name: | Non-receptor tyrosine-protein kinase TNK1 |
UniProt Synonym Protein Names: | CD38 negative kinase 1 |
Protein Family: | Non-receptor tyrosine-protein kinase |
UniProt Gene Name: | TNK1 |
UniProt Entry Name: | TNK1_HUMAN |
Antibodies |
TNK1 Antibody (PACO12831) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |