TNFSF9 Antibody (PACO32540)
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주문- SKU:
- PACO32540
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TNFSF9 Antibody (PACO32540) |
Antibody SKU: | PACO32540 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Tumor necrosis factor ligand superfamily member 9 protein (52-254AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO32540 at dilution of 1:100. | |
Immunofluorescence staining of Hela cells with PACO32540 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. |
Synonyms: | Tumor necrosis factor ligand superfamily member 9 (4-1BB ligand) (4-1BBL), TNFSF9 |
UniProt Protein Function: | TNFL9: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. Belongs to the tumor necrosis factor family. |
UniProt Protein Details: | Protein type:Apoptosis; Cell cycle regulation; Cytokine; Membrane protein, integral Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: plasma membrane Molecular Function:receptor binding; tumor necrosis factor receptor superfamily binding Biological Process: apoptosis; cell proliferation; cell-cell signaling; positive regulation of activated T cell proliferation; positive regulation of cytotoxic T cell differentiation; signal transduction; tumor necrosis factor-mediated signaling pathway |
NCBI Summary: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008] |
UniProt Code: | P41273 |
NCBI GenInfo Identifier: | 728739 |
NCBI Gene ID: | 8744 |
NCBI Accession: | P41273.1 |
UniProt Secondary Accession: | P41273,Q2M3S2, |
UniProt Related Accession: | P41273 |
Molecular Weight: | 27kDa |
NCBI Full Name: | Tumor necrosis factor ligand superfamily member 9 |
NCBI Synonym Full Names: | TNF superfamily member 9 |
NCBI Official Symbol: | TNFSF9 |
NCBI Official Synonym Symbols: | CD137L; TNLG5A; 4-1BB-L |
NCBI Protein Information: | tumor necrosis factor ligand superfamily member 9 |
UniProt Protein Name: | Tumor necrosis factor ligand superfamily member 9 |
UniProt Synonym Protein Names: | 4-1BB ligand; 4-1BBL |
Protein Family: | Tumor necrosis factor ligand superfamily |
UniProt Gene Name: | TNFSF9 |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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