TNFSF12 Antibody (PACO12826)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO12826
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TNFSF12 Antibody (PACO12826) |
Antibody SKU: | PACO12826 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human TNFSF12 |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | tumor necrosis factor (ligand) superfamily, member 12;TNFSF12;APO3L;DR3LG;MGC129581;MGC20669;TWEAK ; |
UniProt Protein Function: | TNFSF12: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Homotrimer (Potential). Interacts with the angiogenic factor AGGF1/VG5Q. Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain. Belongs to the tumor necrosis factor family. |
UniProt Protein Details: | Protein type:Apoptosis; Membrane protein, integral; Motility/polarity/chemotaxis; Cytokine Chromosomal Location of Human Ortholog: 17p13 Cellular Component: extracellular space; perinuclear region of cytoplasm; integral to plasma membrane Molecular Function:protein binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding Biological Process: positive regulation of angiogenesis; apoptosis; positive regulation of protein catabolic process; endothelial cell migration; immune response; positive regulation of endothelial cell proliferation; angiogenesis; cell differentiation; signal transduction |
NCBI Summary: | This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43508 |
NCBI GenInfo Identifier: | 21362987 |
NCBI Gene ID: | 407977 |
NCBI Accession: | O43508.1 |
UniProt Secondary Accession: | O43508,Q8IZK7, Q8WUZ7, |
Molecular Weight: | 36,589 Da |
NCBI Full Name: | Tumor necrosis factor ligand superfamily member 12 |
NCBI Synonym Full Names: | TNFSF12-TNFSF13 readthrough |
NCBI Official Symbol: | TNFSF12-TNFSF13 |
NCBI Official Synonym Symbols: | TWE-PRIL |
NCBI Protein Information: | TNFSF12-TNFSF13 protein; tumor necrosis factor (ligand) superfamily, member 12-member 13 |
UniProt Protein Name: | Tumor necrosis factor ligand superfamily member 12 |
UniProt Synonym Protein Names: | APO3 ligand; TNF-related weak inducer of apoptosis; TWEAK |
UniProt Gene Name: | TNFSF12 |
UniProt Entry Name: | TNF12_HUMAN |