TNFRSF10D Antibody (PACO22819)
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주문- SKU:
- PACO22819
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TNFRSF10D Antibody (PACO22819) |
Antibody SKU: | PACO22819 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from internal of human TNFRSF10D. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from Jurkat cells, using TNFRSF10D antibody. |
Background: | Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to it cannot but according to it can induce the NF-kappa-B pathway. |
Synonyms: | Tumor necrosis factor receptor superfamily member 10D; Decoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4 |
UniProt Protein Function: | TRAIL-R4: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway. Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 8p21 Cellular Component: integral to membrane Molecular Function:transmembrane receptor activity; TRAIL binding Biological Process: apoptosis; signal transduction; negative regulation of apoptosis |
NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UBN6 |
NCBI GenInfo Identifier: | 18203495 |
NCBI Gene ID: | 8793 |
NCBI Accession: | Q9UBN6.1 |
UniProt Secondary Accession: | Q9UBN6,Q9Y6Q4, B2R8W0, |
UniProt Related Accession: | Q9UBN6 |
Molecular Weight: | 41,823 Da |
NCBI Full Name: | Tumor necrosis factor receptor superfamily member 10D |
NCBI Synonym Full Names: | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain |
NCBI Official Symbol: | TNFRSF10D |
NCBI Official Synonym Symbols: | DCR2; CD264; TRUNDD; TRAILR4; TRAIL-R4 |
NCBI Protein Information: | tumor necrosis factor receptor superfamily member 10D; TRAIL receptor 4; decoy receptor 2; TNF receptor-related receptor for TRAIL; TRAIL receptor with a truncated death domain; TNF-related apoptosis-inducing ligand receptor 4 |
UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 10D |
UniProt Synonym Protein Names: | Decoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death domain; CD_antigen: CD264 |
Protein Family: | Tumor necrosis factor receptor superfamily |
UniProt Gene Name: | TNFRSF10D |
UniProt Entry Name: | TR10D_HUMAN |
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