TMPRSS15 Antibody (PACO45375)
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주문- SKU:
- PACO45375
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IP
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TMPRSS15 Antibody (PACO45375) |
Antibody SKU: | PACO45375 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IP |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IP:1:200-1:2000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Enteropeptidase protein (40-300AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO45375 at dilution of 1:100. | |
Immunoprecipitating PRSS7 in Jurkat whole cell lysate. Lane 1: Rabbit control IgG instead of PACO45375 in Jurkat whole cell lysate.For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000). Lane 2: PACO45375 (8µg) + Jurkat whole cell lysate (500µg). Lane 3: Jurkat whole cell lysate (10µg). |
Background: | Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. |
Synonyms: | Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain], TMPRSS15, ENTK PRSS7 |
UniProt Protein Function: | PRSS7: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. Defects in TMPRSS15 are a cause of enterokinase deficiency (ENTKD); a life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive. Belongs to the peptidase S1 family. |
UniProt Protein Details: | Protein type:EC 3.4.21.9; Membrane protein, integral; Protease Chromosomal Location of Human Ortholog: 21q21.1 Cellular Component: brush border Molecular Function:protein binding Disease: Enterokinase Deficiency |
NCBI Summary: | This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008] |
UniProt Code: | P98073 |
NCBI GenInfo Identifier: | 317373442 |
NCBI Gene ID: | 5651 |
NCBI Accession: | P98073.3 |
UniProt Secondary Accession: | P98073,Q2NKL7, |
UniProt Related Accession: | P98073 |
Molecular Weight: | Calculated MW: 112kDaObserved MW: 113kDa |
NCBI Full Name: | Enteropeptidase |
NCBI Synonym Full Names: | transmembrane protease, serine 15 |
NCBI Official Symbol: | TMPRSS15 |
NCBI Official Synonym Symbols: | ENTK; PRSS7 |
NCBI Protein Information: | enteropeptidase |
UniProt Protein Name: | Enteropeptidase |
UniProt Synonym Protein Names: | Enterokinase; Serine protease 7; Transmembrane protease serine 15 |
Protein Family: | Enteropeptidase |
UniProt Gene Name: | TMPRSS15 |
Antibodies | ELISA Kits |
Anti-TMPRSS15 Antibody (CAB10239) | Human TMPRSS15 (Enteropeptidase) ELISA Kit (HUFI03456) |
TMPRSS15 Antibody (PACO04776) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |