TMEM67 Antibody (PACO36178)
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주문- SKU:
- PACO36178
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TMEM67 Antibody (PACO36178) |
Antibody SKU: | PACO36178 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Meckelin protein (241-500AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO36178 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO36178 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO36178 at dilution of 1:100. |
Background: | Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). |
Synonyms: | Meckelin (Meckel syndrome type 3 protein) (Transmembrane protein 67), TMEM67, MKS3 |
UniProt Protein Function: | Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). |
NCBI Summary: | The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). [provided by RefSeq, Nov 2008] |
UniProt Code: | Q5HYA8 |
NCBI GenInfo Identifier: | 214830753 |
NCBI Gene ID: | 91147 |
NCBI Accession: | NP_001135773.1 |
UniProt Secondary Accession: | Q5HYA8,Q3ZCX3, Q7Z5T8, Q8IZ06, B3KRU5, B3KT47, G5E9H2 |
UniProt Related Accession: | Q5HYA8 |
Molecular Weight: | Observed: 112 kDPredicted: 112 kDa |
NCBI Full Name: | meckelin isoform 2 |
NCBI Synonym Full Names: | transmembrane protein 67 |
NCBI Official Symbol: | TMEM67 |
NCBI Official Synonym Symbols: | MKS3; JBTS6; NPHP11; TNEM67; MECKELIN |
NCBI Protein Information: | meckelin |
UniProt Protein Name: | Meckelin |
UniProt Synonym Protein Names: | Meckel syndrome type 3 protein; Transmembrane protein 67 |
UniProt Gene Name: | TMEM67 |