TIMP3 Antibody (PACO13638)
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주문- SKU:
- PACO13638
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TIMP3 Antibody (PACO13638) |
Antibody SKU: | PACO13638 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human Timp-3 |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | TIMP metallopeptidase inhibitor 3;TIMP3;HSMRK222;K222;K222TA2;SFD ; |
UniProt Protein Function: | TIMP3: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Interacts with EFEMP1. Belongs to the protease inhibitor I35 (TIMP) family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 22q12.3 Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; basement membrane; nucleus Molecular Function:metalloendopeptidase inhibitor activity; protein binding; protease binding; metal ion binding Biological Process: negative regulation of metalloenzyme activity; visual perception; response to cytokine stimulus; response to hormone stimulus; negative regulation of membrane protein ectodomain proteolysis Disease: Fundus Dystrophy, Pseudoinflammatory, Of Sorsby |
NCBI Summary: | This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008] |
UniProt Code: | P35625 |
NCBI GenInfo Identifier: | 730948 |
NCBI Gene ID: | 7078 |
NCBI Accession: | P35625.2 |
UniProt Secondary Accession: | P35625,Q5THV4, Q9UC74, Q9UGS2, B2RBY9, |
UniProt Related Accession: | P35625 |
Molecular Weight: | 24,145 Da |
NCBI Full Name: | Metalloproteinase inhibitor 3 |
NCBI Synonym Full Names: | TIMP metallopeptidase inhibitor 3 |
NCBI Official Symbol: | TIMP3 |
NCBI Official Synonym Symbols: | SFD; K222; K222TA2; HSMRK222 |
NCBI Protein Information: | metalloproteinase inhibitor 3; TIMP-3; MIG-5 protein; protein MIG-5; tissue inhibitor of metalloproteinases 3 |
UniProt Protein Name: | Metalloproteinase inhibitor 3 |
UniProt Synonym Protein Names: | Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3 |
Protein Family: | Metalloproteinase inhibitor |
UniProt Gene Name: | TIMP3 |
UniProt Entry Name: | TIMP3_HUMAN |